Effects of a Carob-Pod-Derived Sweetener on Glucose Metabolism

Nutrients
Carmen LambertLina Badimon

Abstract

Patients with type 2 diabetes mellitus (T2DM) have a higher incidence of cardiovascular (CV) events. The ingestion of high-glycemic index (GI) diets, specially sweetened beverage consumption, has been associated with the development of T2DM and CV disease. We investigated the effects of the intake of a sweetened beverage, obtained from natural carbohydrates containing pinitol (PEB) compared to a sucrose-enriched beverage (SEB) in the context of impaired glucose tolerance (IGT) and diabetes. The study was divided in three different phases: (1) a discovery phase where the plasma proteomic profile was investigated by 2-DE (two-dimensional electrophoresis) followed by mass spectrometry (matrix-assisted laser desorption/ionization time-of-flight-MALDI-TOF/TOF) in healthy and IGT volunteers; (2) a verification phase where the potential mechanisms behind the observed protein changes were investigated in the discovery cohort and in an additional group of T2DM volunteers; and (3) the results were validated in a proof-of-concept interventional study in an animal model of diabetic rats with complementary methodologies. Six weeks of pinitol-enriched beverage (PEB) intake induced a significant increase in two proteins involved in the insuli...Continue Reading

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Methods Mentioned

BETA
electrophoresis
ELISA
PCR

Clinical Trials Mentioned

NCT01754792

Software Mentioned

Stat View
Image Lab
MASCOT
flexAnalysis
BioTools
PD
Quest

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