Effects of a combined thermochemotherapy on the xenotransplanted human mammary carcinoma MX-1. A light and transmission electron microscopic study

Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft
E M Stobbe

Abstract

A thermochemotherapy (TCT), consisting of the administration of the alkylating agent ifosfamide combined with whole body hyperthermia at 41 degrees C for one hour applied to the xenotransplanted human mammary carcinoma MX-1, leads to a complete remission within one week. This light and transmission electron microscopical study concentrates upon the mechanisms of cell death and upon therapy-induced changes in vasculature. These showed that TCT produces necrotic rather than apoptotic cell death in xenotransplanted MX-1 tumors, whereas apoptosis of endothelial cells was often found. We therefore conclude from our experiments that TCT is a very powerful stimulus which directly impels MX-1 cells towards coagulative necrosis, while endothelial cells, being probably more resistant, often die by apoptosis.

References

Jun 1, 1994·Clinical Pharmacokinetics·T Wagner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft
A MendozaW Kühnel
Cancer Metastasis Reviews
A E Cress, W S Dalton
International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
R Valdagni
© 2022 Meta ULC. All rights reserved