PMID: 6414283Oct 1, 1983Paper

Effects of a commercial starch blocker preparation on carbohydrate digestion and absorption: in vivo and in vitro studies

The American Journal of Clinical Nutrition
C B HollenbeckG M Reaven

Abstract

We have tested the effectiveness of a commercial starch blocker on the digestion and absorption of dietary carbohydrates in six normal, healthy volunteers. The effectiveness of the starch blocker to attenuate or block the digestion of carbohydrate was assessed against a placebo by the measurement of end tidal breath hydrogen, plasma glucose, and insulin responses to a constant test meal. There were no significant differences in breath hydrogen, or plasma glucose and insulin responses. In vitro enzyme inhibition studies assessed the ability of the brush border enzyme maltase/glucoamylase to degrade starch in the presence of the starch blockers. A highly purified solution of rat and human maltase/glucoamylase was capable of degrading a starch solution, while 40 mM Tris-HCl (a known maltase/glucoamylase inhibitor) completely abolished the enzyme activity. These data challenge the claims that starch blocker preparations are effective in reducing or attenuating the absorption of carbohydrates or calories from a mixed meal. The ineffectiveness in vivo could be explained, in part, by the ability of the brush border enzyme maltase/glucoamylase to hydrolyze starch in the presence of starch blockers.

Citations

Feb 1, 1985·Nutrition Reviews
Aug 1, 2007·Journal of Veterinary Pharmacology and Therapeutics·J GossellinS J Sunderland
Feb 13, 2010·Journal of the American College of Nutrition·Harry G Preuss
Jun 4, 2008·Journal of the American Veterinary Medical Association·Philip RoudebushSean J Delaney
Dec 25, 2002·The British Journal of Nutrition·Martine M-J Champ
Jul 28, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·N D YulianaR Verpoorte
Mar 1, 2010·Journal of Dietary Supplements·Catherine UlbrichtWendy Weissner
Mar 12, 2008·The British Journal of Nutrition·Wokadala Cuthbert ObiroBo Jiang
Nov 10, 2004·Medical Hypotheses·Mark F McCarty

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