Effects of a Dendroaspis neurotoxin on synaptic transmission in the spinal cord and the neuromuscular junction of the frog

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
B P FultonA C Szczepaniak

Abstract

A neurotoxin from the venom of Dendroaspis jamesoni was tested at the neuromuscular junction and at a cholinergic pathway in the isolated spinal cord of the frog. The toxin reduced the amplitude and time constant of decay of miniature endplate currents in the presence of prostigmine, indicating a curare-like action. In the spinal cord it selectively blocked transmission in the cholinergic pathway and increased spontaneous activity. Partial protection against toxin action in the spinal cord was provided by atropine or carbachol. The results suggest that the toxin acts on cholinergic receptors at both sites and also provide further evidence that the pharmacology of the two sites is different.

References

Jul 1, 1975·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R Miledi, A C Szczepaniak
Oct 29, 1971·Nature·R Miledi, L T Potter
Feb 1, 1966·The Journal of Physiology·A D Grinnell
Nov 1, 1967·Comparative Biochemistry and Physiology·J W Phillis, A K Tebĕcis
Oct 1, 1961·British Journal of Pharmacology and Chemotherapy·J K KIRALY, J W PHILLIS

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Citations

Jul 1, 1991·British Journal of Industrial Medicine·T P NgJ Jeyaratnam
Dec 1, 1989·Acta Physiologica Scandinavica·B C ShyuB Rydenhag
Jan 1, 1982·Neir̆ofiziologiia = Neurophysiology·V V Marlinskiĭ
Oct 14, 2020·Nature Protocols·Lixia Gao, Xiaoqin Wang

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