Effects of a dimeric vs a monomeric nonionic contrast medium on renal function in patients with mild to moderate renal insufficiency: a double-blind, randomized clinical trial

European Radiology
M CarraroL Faccini

Abstract

The efficacy and safety of nonionic dimeric contrast media in subjects with impaired renal function is largely unknown. The present study was aimed at determining the risk of tubular nephrotoxicity in patients with mild to moderate renal insufficiency who underwent intravenous urography (IVU) with the nonionic dimeric contrast agent iodixanol (Visipaque, Nycomed Imaging, Oslo, Norway). In a double-blind protocol 64 patients (55 males; mean age 68.3 years) with serum creatinine between 135 and 265 micromol/l who were to undergo IVU were randomized to receive iodixanol (a nonionic dimer) or iopromide (a nonionic monomer), 600 mg I/kg b. w. Renal function was evaluated before and 1 h, 6 h, 24 h, 48 h and 7 days after IVU with analysis of serum creatinine, urinary enzymes alanylaminopeptidase and N-acetyl-beta-glucosaminidase, and urinary microproteins alpha-1-microglobulin and albumin. Renal function remained stable in both contrast medium groups during the follow-up period. No statistically significant differences were observed between the monomer and the dimer in terms of urinary enzyme and microprotein excretion or serum creatinine. Transient radiocontrast-induced nephropathy developed in 1 patient who had received iodixanol. T...Continue Reading

Citations

Jul 27, 2007·La Radiologia medica·H S Thomsen
Jun 1, 2005·Seminars in Interventional Radiology·Brian Funaki
Feb 7, 2003·The New England Journal of Medicine·Peter AspelinUNKNOWN Nephrotoxicity in High-Risk Patients Study of Iso-Osmolar and Low-Osmolar Non-Ionic Contrast Media Study Investigators
Jan 24, 2012·European Heart Journal·Erdmann SeeligerPontus B Persson
Nov 5, 1999·Investigative Radiology·S N HeymanM Brezis
Dec 20, 2007·Current Opinion in Nephrology and Hypertension·Sushrut S Waikar, Joseph V Bonventre
Oct 23, 2008·Current Opinion in Nephrology and Hypertension·Kevin A SterlingMichael R Rudnick
Feb 28, 2008·Investigative Radiology·Henrik S ThomsenUNKNOWN Investigators in the Abdominal Computed Tomography: IOMERON 400 Versus VISIPAQUE 320 Enhancement (ACTIVE) Study
May 26, 2010·Investigative Radiology·Jian Li, Richard J Solomon
Oct 15, 2008·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Jay P Heiken
Jul 25, 2003·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Sameer JunnarkarChee V Soong
Jan 31, 2013·Radiology·Robert J McDonaldDavid F Kallmes
Apr 21, 2007·Radiology·Richard W Katzberg, Brendan J Barrett
Aug 26, 2011·European Radiology·Fulvio StaculUNKNOWN Contrast Media Safety Committee of European Society of Urogenital Radiology (ESUR)
Jan 7, 2000·The British Journal of Radiology·N Chalmers, R W Jackson
Jan 27, 2006·The New England Journal of Medicine·Brendan J Barrett, Patrick S Parfrey
Apr 14, 2006·Kidney International. Supplement·R SolomonM Bettmann
Apr 17, 2008·Journal of Diabetes and Its Complications·Kathy J HardiekCharles E Katholi
Aug 19, 2007·The Journal of Urology·Simona DetrenisGiorgio Savazzi
Oct 14, 2009·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Bassam G Abu JawdehJeffrey R Schelling
Aug 6, 2010·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Daniel B MarkUNKNOWN American College of Cardiology Foundation Task Force on Expert Consensus Documents
Sep 5, 2006·The American Journal of Cardiology·Peter A McCulloughUNKNOWN CIN Consensus Working Panel
Sep 5, 2006·The American Journal of Cardiology·James TumlinUNKNOWN CIN Consensus Working Panel
Sep 5, 2006·The American Journal of Cardiology·Charles DavidsonUNKNOWN CIN Consensus Working Panel
Aug 15, 2006·Journal of the American College of Cardiology·Peter A McCulloughFulvio Stacul
Mar 10, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M H WijnenR M Roumen
Feb 13, 2007·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Stewart R WalshJonathan R Boyle
May 7, 2014·BioMed Research International·Andreas M BucherRichard W Katzberg
Apr 28, 2005·Journal of Intensive Care Medicine·Steven D Weisbord, Paul M Palevsky

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.