Effects of a flavonoid extract from Cynomorium songaricum on the swimming endurance of rats

The American Journal of Chinese Medicine
Fa-Rong YuFa-Hong Yu

Abstract

The present study investigated the effects of a flavonoid extract from Cynomorium songaricum on the swimming endurance of rats by measuring changes of free radical scavenging enzymes, such as CuZn-SOD (copper, zinc-superoxide dismutase) and GSH-px (glutathione peroxidase), and body weights. Significant and dose-dependent antioxidant and anti-fatigue effects of flavonoids (rutin, catechin and isoquercitrin) on swimming rats were observed during 10 days of swimming exercise. After treatment with the flavonoid extract at doses of 0.5, 1.0, and 2.0 g/kg body weight, the CuZn-SOD and GSH-px activities in swimming rats were increased by 1.4%, 3.3%, 4.1% and 112.2%, 208.7%, 261.7%, respectively, while the levels of MDA (malondialdehyde) were decreased by 64.7%, 79.4%, and 86.4% respectively. Furthermore, the average body weight and the total swimming time were increased by 3.1%, 8.8%, 10.6%, and 7.7%, 34.5%, 61.5%, respectively. Our experimental results suggest that flavonoid supplementation could not only reduce free radical formation and scavenge free radicals, but also enhance endurance exercise performance by reducing muscle fatigue.

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Citations

Dec 21, 2010·Free Radical Biology & Medicine·Scott K PowersMatthew B Hudson
Jul 26, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Chi-Chang HuangChia-Chung Hou
Feb 2, 2013·Journal of Ethnopharmacology·Zhanhu CuiMinhui Li
Jul 31, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Hsin-Ping LiuFuu-Jen Tsai
Feb 3, 2012·The American Journal of Chinese Medicine·Na-Hyung KimHyun-Ja Jeong
Apr 2, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yin LinKe Yuan
Jan 16, 2016·Preventive Nutrition and Food Science·Gong-Hyeon LeeYong-Ki Hong
Sep 24, 2013·Natural Product Reports·Aikaterini ArgyropoulouAlexios-Leandros Skaltsounis
Dec 26, 2017·The Journal of Veterinary Medical Science·Chien-Yu HsiaoCity C Hsieh
Aug 28, 2020·Food Research International·Ricardo de Andrade SoaresAngela Castro Resende

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