Effects of a Flavonoid-Rich Fraction on the Acquisition and Extinction of Fear Memory: Pharmacological and Molecular Approaches

Frontiers in Behavioral Neuroscience
Daniela Rodrigues de OliveiraSuzete M Cerutti

Abstract

The effects of flavonoids have been correlated with their ability to modulate the glutamatergic, serotoninergic, and GABAergic neurotransmission; the major targets of these substances are N-methyl-D-aspartic acid receptor (NMDARs), serotonin type1A receptor (5-HT1ARs), and the gamma-aminobutyric acid type A receptors (GABAARs). Several studies showed that these receptors are involved in the acquisition and extinction of fear memory. This study assessed the effects of treatment prior to conditioning with a flavonoid-rich fraction from the stem bark of Erythrina falcata (FfB) on the acquisition and extinction of the conditioned suppression following pharmacological manipulations and on gene expression in the dorsal hippocampus (DH). Adult male Wistar rats were treated before conditioned fear with FfB, vehicle, an agonist or antagonist of the 5-HT1AR, GABAARs or the GluN2B-NMDAR or one of these antagonists before FfB treatment. The effects of these treatments on fear memory retrieval, extinction training and extinction retrieval were evaluated at 48, 72, and 98 h after conditioning, respectively. We found that activation of GABAARs and inactivation of GluN2B-NMDARs play important roles in the acquisition of lick response suppressi...Continue Reading

References

May 1, 1992·Science·J J Kim, M S Fanselow
Jul 1, 1991·Trends in Pharmacological Sciences·I Izquierdo, J H Medina
Jan 1, 1992·Physiological Reviews·B L Jacobs, E C Azmitia
Apr 1, 1988·Behavioral Neuroscience·M S Fanselow, F J Helmstetter
May 1, 1969·Journal of Comparative and Physiological Psychology·R J Blanchard, D C Blanchard
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Oct 4, 1996·The Journal of Biological Chemistry·J D English, J D Sweatt
Dec 23, 1998·Psychopharmacology·J A Harris, R F Westbrook
Apr 10, 1999·Nature Neuroscience·C M AtkinsJ D Sweatt
Apr 22, 1999·General Pharmacology·L Gamet-PayrastreB Payrastre
Jul 7, 1999·Neuroscience and Biobehavioral Reviews·M Fendt, M S Fanselow
Aug 26, 1999·Neuropharmacology·N M Barnes, T Sharp
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I K WangJ K Lin
Oct 19, 2000·Brain Research. Molecular Brain Research·S Malkani, J B Rosen
Dec 26, 2001·Neurobiology of Learning and Memory·Mariana AlonsoJorge H Medina
Oct 24, 2002·Neurobiology of Aging·Hagen SchroeterCatherine Rice-Evans
Nov 21, 2002·Neuron·Karyn M Myers, Michael Davis
Feb 26, 2003·European Journal of Pharmacology·Matthew J SandersMichael S Fanselow
Mar 26, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Victoria B RisbroughMark A Geyer
Mar 10, 2004·Pharmacology, Biochemistry, and Behavior·John R HoffmanSteven J Robbins
Apr 16, 2004·The Journal of Clinical Investigation·Janete M CeruttiGregory J Riggins
May 13, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nora A IsoardiVíctor A Molina
Jul 1, 2004·Neuroscience and Biobehavioral Reviews·D M BannermanJ Feldon
Jul 1, 2004·Neuroscience and Biobehavioral Reviews·Neil McNaughton, Philip J Corr
Oct 7, 2004·Learning & Memory·Robert A Rescorla
Oct 8, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiao-Bo LiuEdward G Jones

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