PMID: 3764340Aug 1, 1986Paper

Effects of a hemoregulatory peptide (HP5b) on erythroid and myelopoietic colony formation in vitro

Scandinavian Journal of Haematology
L KrejaW R Paukovits

Abstract

A hemoregulatory peptide (HP5b) associated with mature human granulocytes has been investigated for inhibitory effects on murine hemopoietic stem cells in vitro. Both highly purified peptide from natural sources and a synthetic analog peptide have been investigated in parallel. Strong inhibitory effects were found on myelopoietic colony formation in the dose range 10(-13)-10(-5) mol/l. On exceeding this dose, the inhibitory effect disappeared. Moderate to slight inhibitory effects on erythroid colony formation (BFU-E and CFU-E) from adult animals were only seen in 1,000 X the optimal doses for myelopoiesis. No effect was found on CFU-E from fetal liver. The peptide thus has a selective effect on myelopoiesis in a certain dose range. A regulatory mechanism for the peptide on hemopoiesis is proposed.

References

May 3, 1977·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·N P AardalH R Maurer
Jul 14, 1978·Blut·W R Paukovits, W Hinterberger
Dec 17, 1973·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·O D Laerum, H R Maurer
Dec 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·Y MoriyamaJ W Fisher
Jan 1, 1984·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·O D Laerum, W R Paukovits
Apr 1, 1983·Hoppe-Seyler's Zeitschrift für physiologische Chemie·W R PaukovitsA M Rogan
Oct 1, 1983·British Journal of Haematology·A Jacobs
Jan 1, 1984·Differentiation; Research in Biological Diversity·O D Laerum, W R Paukovits
Mar 1, 1984·Hoppe-Seyler's Zeitschrift für physiologische Chemie·W R Paukovits, O D Laerum
Nov 1, 1982·Zeitschrift Für Naturforschung. Section C: Biosciences·W R Paukovits, O D Laerum

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