PMID: 15242014Jul 10, 2004Paper

Effects of a high-monounsaturated fat diet on glucose and lipid metabolisms in normal and diabetic mice

Journal of Nutritional Science and Vitaminology
Jiro KotakeHiroyoshi Mizote

Abstract

The beneficial effects of high-monounsaturated fat (high-MUFA) diets on diabetic patients have been reported, whereas studies concerning the effects on animals have been few. Although experiments on animals should be useful in elucidating underlying mechanisms, it is not clear even whether there are benefits of a high-MUFA diet in animals. This study examined the short-term effects of a high-MUFA diet on normal and genetically diabetic mice. The high-MUFA diet supplied 38% of the total calories as fat (26% from MUFA), while a regular diet was 13% fat (3% from MUFA). Normal C5 7BL/6J and diabetic C57BL/KsJ-db/db mice were fed either the regular or the high-MUFA diet for 1 wk. Serum glucose and lipid levels were then measured. In normal mice, hepatic triglyceride production was also compared between the two dietary groups using the Triton WR1339 method. An oral glucose tolerance test was conducted on the diabetic mice. After 1 wk of feeding to normal mice, the high-MUFA diet was seen to lower serum triglyceride levels and reduce hepatic triglyceride production in comparison with the regular diet; it is suggested that the lowering of triglyceride consists of mechanisms including reduced hepatic triglyceride production. When diabet...Continue Reading

Citations

Mar 31, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R PoonG Pelletier
Dec 8, 2006·Annals of the New York Academy of Sciences·M Al-Haj AliE Adeghate
Feb 14, 2006·Diabetes Technology & Therapeutics·Lucy M Browning, Susan A Jebb

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