Effects of a high plant protein diet on the somatotropic system and cholecystokinin in Atlantic salmon (Salmo salar L.)

Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
E M HevrøyMarit Espe

Abstract

To investigate the endocrine signalling from dietary plant protein on somatotropic system and gastrointestinal hormone cholecystokinin (CCK), two iso-amino acid diets based on either high plant or high fish meal protein were fed to Atlantic salmon. Salmon with an average starting weight of 641+/-23 g (N=180), were fed a fish meal (FM) based diet (containing 40% FM) or diets mainly consisting of blended plant proteins (PP) containing only 13% marine protein, of which only 5% was FM for 3 months. mRNA levels of target genes GH, GH-R, IGF-I, IGF-II, IGFBP-1, IGF-IR in addition to CCK-L, were studied in brain, hepatic tissue and fast muscle, and circulating levels of IGF-I in plasma of Atlantic salmon were measured. We detected reduced feed intake resulting in lower growth, weight gain and muscle protein accretion in salmon fed plant protein compared to a diet based on fish meal. There were no significant effects on the regulation of the target genes in brain or in hepatic tissues, but a trend of down-regulation of IGF-I was detected in fast muscle. Lower feed intake, and therefore lower intake of the indispensable amino acids, may have resulted in lower pituitary GH and lower IGF-I mRNA levels in muscle tissues. This, together wit...Continue Reading

References

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Sep 16, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·X LinR E Peter
Sep 19, 2000·Bioscience, Biotechnology, and Biochemistry·S MoriyamaH Kawauchi
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Dec 6, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Hélène Volkoff
Apr 3, 2007·General and Comparative Endocrinology·E M HevrøyM Espe
Jun 15, 2007·BMC Molecular Biology·Pål A OlsvikErnst M Hevrøy

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Citations

Jul 6, 2012·Fish Physiology and Biochemistry·P EnesA Oliva-Teles
Sep 20, 2012·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Ernst M HevrøyTom Hansen
Oct 28, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Hélène VolkoffJosé Eurico Possebon Cyrino
Apr 20, 2019·Journal of Neurosciences in Rural Practice·Shamila Mohamed AliAnita Mahadevan
Nov 1, 2011·General and Comparative Endocrinology·E M HevrøyT Hansen

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