Effects of a high-protein intake on metabolic targets for weight loss in children with obesity: a randomized trial

Obesity Science & Practice
M A B VeldhorstE L T van den Akker

Abstract

The objective of this research is to study effects of a 4-week high-protein (HP) diet on energy intake, resting energy expenditure (REE), protein turnover and body composition in children with obesity. In this randomized placebo-controlled single-blind crossover study, children with obesity (n = 14; mean age: 10.1 years ± 1.2 standard deviation; body mass index-standard deviation score [BMI-SDS]: 2.8 ± 0.5) received an ad libitum HP (+50 g protein per day) or normal-protein (NP) diet for 4 weeks with a washout period of ≥2 weeks. Energy intake, REE, protein turnover, weight, BMI-SDS and body composition were measured. No differences were found in energy intake or REE between HP and NP. There was an increased urea production and phenylalanine hydroxylation after HP compared with NP (p < 0.05). There was an increased rise in fat-free mass after HP compared with NP (∆HP: 0.8 ± 0.8 kg vs. ∆NP: 0.1 ± 0.6 kg, p < 0.05). BMI and BMI-SDS increased during the study (BMI-SDS start: 2.8 ± 0.5, end: 2.9 ± 0.5, p < 0.05) without a difference between groups. A 4-week HP diet with ad libitum food intake did not affect energy intake and energy expenditure in children with obesity. BMI increased, although that could be partly explained by an in...Continue Reading

References

Mar 1, 1991·The British Journal of Nutrition·P DeurenbergJ C Seidell
Jul 1, 1994·The American Journal of Clinical Nutrition·J S MarchiniV R Young
Jul 14, 1999·European Journal of Clinical Nutrition·M S Westerterp-PlantengaK R Westerterp
Feb 18, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M F Rolland-CacheraP Serog
Jun 4, 2004·The New England Journal of Medicine·Ram WeissSonia Caprio
Mar 25, 2005·The British Journal of Nutrition·Manuela P G M LejeuneMargriet S Westerterp-Plantenga
Sep 9, 2006·The American Journal of Clinical Nutrition·Robert R Wolfe
Sep 29, 2007·International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity·Tim Lobstein, Rachel Jackson-Leach
Jan 12, 2008·Journal of Applied Physiology·Shaji K ChackoMorey W Haymond
Feb 20, 2008·Physiology & Behavior·M VeldhorstM Westerterp-Plantenga
Mar 12, 2008·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A S SinghM J M Chinapaw
Dec 6, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Mylène PotierDaniel Tomé
Jan 30, 2009·The American Journal of Clinical Nutrition·Ananda Hochstenbach-WaelenKlaas R Westerterp
Apr 30, 2009·Annual Review of Nutrition·M S Westerterp-PlantengaK R Westerterp
Jul 31, 2009·The American Journal of Clinical Nutrition·Margriet A B VeldhorstKlaas R Westerterp
Oct 13, 2009·The Journal of Clinical Endocrinology and Metabolism·Jefferson P LomenickJames W Anderson
Oct 13, 2010·Pediatrics·Angeliki PapadakiUNKNOWN DiOGenes Study Group
Oct 27, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J J Reilly, J Kelly
Dec 15, 2010·Pediatrics·Judith de NietErica van den Akker
May 11, 2013·The Journal of Pediatrics·Hester VlaardingerbroekJohannes B van Goudoever
Jun 7, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stefan M PasiakosAndrew J Young
Oct 30, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S M PasiakosA J Young
Feb 27, 2014·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal
Apr 9, 2014·JAMA Pediatrics·Asheley Cockrell Skinner, Joseph A Skelton

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