Effects of a high-salt diet on TRPV-1-dependent renal nerve activity in Dahl salt-sensitive rats.

American Journal of Nephrology
Chaoqin Xie, Donna H Wang

Abstract

To test the hypothesis that transient receptor potential vanilloid type 1 channel (TRPV1)-mediated increases in afferent renal nerve activity (ARNA) and release of substance P (SP) and calcitonin gene-related peptide (CGRP) from the renal pelvis are suppressed in Dahl salt-sensitive (DS), but not -resistant (DR), rats fed a high-salt (HS) diet. Male DS and DR rats were given a HS or low-salt (LS) diet for 3 weeks. Perfusion of capsaicin (CAP, 10(-6)M), a selective TRPV1 agonist, into the left renal pelvis increased ipsilateral ARNA in all groups, but with a smaller magnitude in DS-HS compared to other groups. CAP increased contralateral urine flow in all groups except DS-HS rats. CAP-induced release of SP and CGRP from the renal pelvis was less in DS-HS compared to other groups. Western blot showed that TRPV1 expression in the kidney decreased while expression of neurokinin 1 receptors increased in DS-HS compared to other groups. TRPV1-mediated increases in ARNA and release of SP and CGRP in the renal pelvis are impaired in DS rats fed a HS diet, which can likely be attributed to suppressed TRPV1 expression in the kidney and contributes to increased salt sensitivity.

References

Sep 25, 1999·Japanese Journal of Pharmacology·T Sasamura, Y Kuraishi
Mar 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·E MezeyA Szallasi
Sep 15, 2001·Nature·D Julius, A I Basbaum
Sep 3, 2002·The Journal of Physiology·Marian Kollarik, Bradley J Undem
Feb 6, 2003·Journal of Hypertension·Donna H Wang, Yajuan Zhao
Jul 23, 2003·Journal of Hypertension·Jianping Li, Donna H Wang
Feb 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D R RobinsonG A Hicks
Aug 16, 2005·Cell Calcium·Stine Falsig PedersenBernd Nilius
Dec 6, 2005·Nature Neuroscience·Reza Sharif NaeiniCharles W Bourque
Jul 11, 2006·Life Sciences·Francis J Haddy
Jun 26, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Beihua Zhong, Donna H Wang
Sep 29, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Bernardo Rodriguez-IturbeRichard J Johnson
Mar 11, 2008·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jianping Li, Donna H Wang
Apr 10, 2008·Journal of Cardiovascular Pharmacology·Yi Zhu, Donna H Wang
Jun 24, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Beihua Zhong, Donna H Wang

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Citations

Aug 16, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Roland Veelken, Johannes F E Mann
Apr 16, 2014·Nature Reviews. Nephrology·Roland Veelken, Roland E Schmieder
Dec 21, 2012·Acta Physiologica·M KassmannM Gollasch
Jan 4, 2013·American Journal of Physiology. Renal Physiology·Wolfgang FreisingerRoland Veelken
Dec 25, 2015·American Journal of Physiology. Renal Physiology·Tilmann DittingRoland Veelken

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