PMID: 43551Jan 1, 1979

Effects of a histamine synthesis inhibitor and antihistamines on the sexual behavior of female rats

Psychopharmacology
A O Donoso, S T Broitman

Abstract

Intraventricular administration of alpha-hydrazinohistidine, a histamine synthesis inhibitor, at different doses and times before testing produced a significant decrease of lordotic responses and sexual receptivity in ovariectomized estrogen plus progesterone-primed female rats. The H1-antihistamines pyrilamine and chlorfeniramine and the H2-antihistamine metiamide, injected in the lateral ventricle, significantly decreased the lordosis quotient but did not modify receptivity; antihistamine-injected rats showed no soliciting behavior. Exploratory activity was decreased by both alpha-hydrazinohistidine and metiamide but not by the H1-antihistamines. It is concluded that treatments which either deplete histamine or block their receptors can alter female copulatory responsiveness. The mechanism of this antihistamine effect appears to be unrelated to that of other side effects, such as motor impairment, sedation, or local anesthesia.

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Citations

Jul 1, 1976·Journal of Medicinal Chemistry·G J DurantR A Slater
Apr 1, 1977·The Journal of Pharmacy and Pharmacology·J M Hind, T J Sutton
Aug 1, 1975·Journal of Reproduction and Fertility·S T Broitman, A O Donoso
Jan 1, 1977·Annual Review of Pharmacology and Toxicology·J C Schwartz
Jan 1, 1975·Journal of Comparative and Physiological Psychology·I L WardF P Zemlan
Aug 15, 1975·Life Sciences·J C Schwartz
Aug 1, 1976·European Journal of Pharmacology·B S Sastry, J W Phillis
Jan 1, 1976·Journal of Neural Transmission·A O Donoso, A M Bannza
Aug 1, 1975·Journal of Comparative and Physiological Psychology·B J EverittG Jonsson
Jan 1, 1976·The Journal of Endocrinology·A O DonosoM I Borzino
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Apr 21, 1972·Nature·J W BlackE M Parsons
Aug 16, 1974·Brain Research·H L Haas
Jun 15, 1970·Life Sciences. Pt. 1: Physiology and Pharmacology·B J Meyerson, T Lewander
Sep 1, 1949·British Journal of Pharmacology and Chemotherapy·N K DUTTA

Related Concepts

Histamine Measurement
Local Anesthesia [PE]
Sexual Receptivity
Pyrilamine
Depression, Chemical
Curiosity
Histamine Biosynthetic Process
Progesterone
Antihistamine [EPC]
Hydrazines

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