PMID: 9438982Jan 24, 1998Paper

Effects of a hydrogenated isomaltooligosaccharide mixture on glucan synthesis and on caries development in rats

Bioscience, Biotechnology, and Biochemistry
J TsunehiroY Takaesu

Abstract

The caries inhibitory effect of the hydrogenated derivative of an isomaltooligosaccharides mixture (IMO-H) was examined in vitro and in vivo experiments. IMO-H could not be used as a substrate for the crude glucosyltransferases (GTases) of Streptococcus sobrinus 6715 to synthesize water-insoluble glucan. Moreover, it not only significantly inhibited the synthesis of water-insoluble glucan from sucrose, but also the sucrose-dependent adherence of these growing cells the glass surfaces. In the in vivo experiment, the addition of IMO-H to a sucrose-containing diet resulted in significant reduction of caries development in specific-pathogen-free (SPF) rats infected with S. sobrinus 6715.

Citations

Jun 18, 2016·Biotechnology Letters·Marilen P BalolongDae-Kyung Kang

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