PMID: 9419252Jan 31, 1998Paper

Effects of a lipophilic environmental pollutant (DDT) on the phospholipid and fatty acid contents of Bacillus stearothermophilus

Archives of Environmental Contamination and Toxicology
M M DonatoV M Madeira

Abstract

Cultures of Bacillus stearothermophilus grown in a complex medium containing 1 microM DDT, exhibited longer lag adapting periods, decreased specific growth rates, and lower growth yield as compared to control cultures. The membrane lipid composition from cells grown in the presence of the insecticide was significantly different from that of control cells. The effects of DDT (2,2-bis(p-chlorophenyl)-1, 1,1-trichloroethane) on growth and lipid composition of bacterial cells were also determined in cultures grown in a medium supplemented with Ca2+ (membrane stabilizer) to further clarify the influence of growth conditions on bacterial responses to the toxicant. The main membrane-lipid changes induced by DDT relate to a very significant increase (74%) of the relative concentration of a phosphoglycolipid, an increase of the phosphatidylethanolamine content, with a parallel decrease of phosphatidylglycerol and an unidentified phospholipid X0. The changes of the phospholipid acyl chains relate to an increase of straight chains and a parallel decrease of branched chains. The effects of DDT-induced lipid composition alterations on membrane physical properties were monitored by fluorescence polarization studies with bacterial polar lipid...Continue Reading

Citations

Dec 3, 2002·Journal of Microbiological Methods·T J DenichJ T Trevors
Nov 6, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J P MonteiroV M C Madeira
Nov 6, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C LuxoM T Silva
May 24, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chao SongLing-Ling Wu
Nov 4, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·George Howell, Lauren Mangum
Jul 25, 2014·International Journal of Microbiology·Slavomíra Murínová, Katarína Dercová
Apr 22, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sandra M A SantosAmália S Jurado
Oct 9, 2014·Environmental Science and Pollution Research International·Karina SałekAgnieszka Zgoła-Grześkowiak
Nov 8, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·S GuptaS V Madhu

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