Effects of a medium chain triglyceride oil mixture and alpha-lipoic acid diet on body composition, antioxidant status, and plasma lipid levels in the Golden Syrian hamster

The Journal of Nutritional Biochemistry
Stephanie D WollinPeter J H Jones

Abstract

The objective of this study was to examine the effects of the antioxidant alpha-lipoic acid (ALP) versus a medium chain triglyceride oil mixture (MCTo), which was designed to increase energy expenditure and to improve lipid profiles containing medium chain triglycerides, phytosterols, and omega-3 fatty acids in the form of flaxseed oil. A total of 48 hamsters were fed a) hypercholesterolemic (HC) control, b) HC MCTo, c) HC ALP, or d) HC MCTo/ALP diet for 4 weeks. No differences were observed on food intake, body weight, total body water, lean and fat mass, and tissue thiobarbituric acid reactive substances (TBARS). ALP alone had no effect on total cholesterol (TC); however, MCTo feeding increased TC with (P < 0.03) and without (P < 0.003) ALP when compared with control. ALP increased HDL levels compared with control (P < 0.04) and MCTo/ALP (P < 0.007) groups. MCTo, with (P < 0.0001) or without (P < 0.006) ALP, increased non-HDL cholesterol levels versus control. The non-HDL:HDL cholesterol ratio was decreased by ALP compared with MCTo (45%) and MCTo/ALP (68%) (P < 0.0001), a similar trend was seen when compared with the HC control (22%) group (P < 0.14). Triglyceride levels were not altered by any dietary treatment. Liver and h...Continue Reading

References

Jan 1, 1992·The American Journal of Clinical Nutrition·W F Caspary
Sep 1, 1990·The American Journal of Clinical Nutrition·R C JohnsonW B Rowe
May 1, 1987·The British Journal of Nutrition·J LeytonM A Crawford
Aug 5, 1988·JAMA : the Journal of the American Medical Association·V ManninenP Koskinen
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M T QuinnD Steinberg
Jan 1, 1983·The American Journal of Clinical Nutrition·A GeliebterT B Van Itallie
Nov 16, 1995·The New England Journal of Medicine·T A MiettinenE Vartiainen
Aug 1, 1995·Free Radical Biology & Medicine·L PackerH J Tritschler
Dec 1, 1993·Journal of the American College of Nutrition·S G HwangR Kawashima
Jan 1, 1996·European Journal of Clinical Pharmacology·C H GleiterU Gundert-Remy
May 1, 1997·The American Journal of Clinical Nutrition·W S Harris
Mar 1, 1997·Canadian Journal of Physiology and Pharmacology·P J JonesC A Vanstone
Aug 22, 1997·The Journal of Biological Chemistry·D Steinberg
Apr 16, 1998·The American Journal of Clinical Nutrition·C BinnertM Laville
Feb 11, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T M HagenA B Ames
May 25, 1999·Metabolism: Clinical and Experimental·H Gylling, T A Miettinen
Feb 17, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·P ArivazhaganC Panneerselvam
Jan 25, 2002·Current Controlled Trials in Cardiovascular Medicine·Curt D Furberg
Jun 28, 2002·Free Radical Biology & Medicine·Wright JonesJames M May
Jan 18, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M-P St-OngeW E Parsons
Mar 14, 2003·Obesity Research·Marie-Pierre St-OngePeter J H Jones

❮ Previous
Next ❯

Citations

Feb 7, 2008·Cardiovascular Drugs and Therapy·François LabartheChristine Des Rosiers
Feb 23, 2007·Nutrition & Metabolism·Caroline RomestaingBrigitte Sibille
Apr 9, 2013·Pharmacological Reports : PR·Anna GorącaBeata Skibska
May 4, 2011·Journal of Animal Physiology and Animal Nutrition·M HalıcıR Gümüş
May 23, 2012·Journal of Dietary Supplements·Scott V HardingPeter J H Jones
Oct 18, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·M Pilar ValdecantosJ Alfredo Martínez
Jun 30, 2011·Cell & Bioscience·Joachim PereraNagaraja Haleagrahara
Feb 7, 2001·Journal of Vascular Surgery·H M HafezG Stansby
Jul 10, 2007·European Journal of Pharmacology·Ganapathy AmudhaPalaninathan Varalakshmi
Mar 31, 2012·Neurobiology of Aging·Shawn N WatsonWillem C Wildering
Apr 7, 2015·Free Radical Biology & Medicine·M Pilar ValdecantosÁngela M Valverde
Nov 1, 2002·The Journal of Pediatrics·Stephen C DonnellAgostino Pierro
Apr 28, 2017·Journal of Animal Physiology and Animal Nutrition·M SohaibS Hussain
Mar 5, 2016·Current Atherosclerosis Reports·Harsh Goel, Richard L Dunbar
Jul 1, 2009·Journal of Nutrition for the Elderly·N ArlappaK Vijayaraghavan
Jan 17, 2007·Molecular and Cellular Biochemistry·Ganapathy AmudhaPalaninathan Varalakshmi
Feb 4, 2021·Comprehensive Reviews in Food Science and Food Safety·Yandan WangXingguo Wang
Jan 1, 2020·Current Protein & Peptide Science·Manyi JiaXi Ma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.