Effects of a modestly lower carbohydrate diet in gestational diabetes: a randomized controlled trial

The American Journal of Clinical Nutrition
Jovana MijatovicJennie C Brand-Miller

Abstract

Lower carbohydrate diets have the potential to improve glycemia but may increase ketonemia in women with gestational diabetes (GDM). We hypothesized that modestly lower carbohydrate intake would not increase ketonemia. To compare blood ketone concentration, risk of ketonemia, and pregnancy outcomes in women with GDM randomly assigned to a lower carbohydrate diet or routine care. Forty-six women aged (mean ± SEM) 33.3 ± 0.6 y and prepregnancy BMI 26.8 ± 0.9 kg/m2 were randomly assigned at 28.5 ± 0.4 wk to a modestly lower carbohydrate diet (MLC, ∼135 g/d carbohydrate) or routine care (RC, ∼200 g/d) for 6 wk. Blood ketones were ascertained by finger prick test strips and 3-d food diaries were collected at baseline and end of the intervention. There were no detectable differences in blood ketones between completers in the MLC group compared with the RC group (0.1 ± 0.0 compared with 0.1 ± 0.0 mmol/L, n = 33, P = 0.31, respectively), even though carbohydrate and total energy intake were significantly lower in the intervention group (carbohydrate 165 ± 7 compared with 190 ± 9 g, P = 0.04; energy 7040 ± 240 compared with 8230 ± 320 kJ, P <0.01, respectively). Only 20% of participants in the MLC group met the target intake compared wi...Continue Reading

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Citations

Dec 4, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Meichen QianAbdulrahman Al-Mureish
Dec 19, 2020·International Journal of Environmental Research and Public Health·Amira Mohammed Ali, Hiroshi Kunugi
Aug 28, 2021·Nutrients·Arianne SweetingTeri L Hernandez
Nov 3, 2021·Journal of Developmental Origins of Health and Disease·Sylvia NorthCaryn Zinn
Jan 21, 2022·The Journal of Nutrition·Emily W FlanaganLeanne M Redman

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