Effects of a new allograft processing procedure on graft healing in a canine model: a preliminary study.

Clinical Orthopaedics and Related Research
Kathleen S BeebeW F Enneking

Abstract

Graft healing in vivo can be affected by allograft processing. We asked whether a new processing technique influenced graft-host healing compared with autograft and a standard processing technique in a canine ulna model. We used bilateral intercalary allografts or autografts in the ulna of 13 skeletally mature male coonhounds. Each animal received two allografts, either one autograft and one allograft, or two autografts. At term (90 days), the graft sites were harvested. We assessed union with high-resolution xray imaging. Each specimen was processed for nondecalcified histologic analysis to assess the graft-host interface. Quantitative histomorphometric analysis was performed to determine spatial location and area of bone. Radiographic analysis, histologic analysis, and histomorphometric measures revealed no differences in union, mean total bone area, or total endosteal/intramedullary bone for the new process, standard process, and autografts. Our preliminary data suggest the new processing techniques may increase the safety of allograft transplantation without adversely affecting union when compared with standard processing techniques and autograft in a canine model.

References

Apr 1, 1975·Archives of Surgery·M R UristS D Boyd
May 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H KienapfelJ O Galante
Sep 1, 1991·The Journal of Bone and Joint Surgery. British Volume·N SchwarzH Redl
Jan 1, 1987·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D C MooreD Manske
Jan 1, 1986·Archives of Orthopaedic and Trauma Surgery·C DelloyeR Bourgois
Aug 1, 1986·The Journal of Bone and Joint Surgery. British Volume·O S NilssonG A Finerman
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M R UristR J DeLange
Jan 1, 1997·British Medical Bulletin·E S Kalter, T M de By
Apr 29, 1998·The Orthopedic Clinics of North America·D S GarbuzA A Czitrom
Sep 3, 1999·The Orthopedic Clinics of North America·W W Tomford, H J Mankin
Sep 3, 1999·The Orthopedic Clinics of North America·T BoyceN Scarborough
Jan 15, 2000·Journal of Biomedical Materials Research·J BeneveniaJ R Parsons
Jun 15, 2000·Clinical Orthopaedics and Related Research·T JinnoS Stevenson
May 17, 2003·The American Journal of Sports Medicine·C Thomas VangsnessTillman M Moore
Sep 4, 2004·Clinical Orthopaedics and Related Research·D Luis MuscoloEduardo Abalo
Jun 3, 2005·Clinical Orthopaedics and Related Research·Nicole P EhrhartRichard W Nicholas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Clinical Orthopaedics and Related Research
Nicole P EhrhartRichard W Nicholas
The Journal of Bone and Joint Surgery. American Volume
H BurchardtW F Enneking
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
P Muir, K A Johnson
© 2022 Meta ULC. All rights reserved