PMID: 2106102Jan 1, 1990Paper

Effects of a new analog of thyrotropin-releasing hormone, N alpha-[(S)-4-oxo-2-azetidinyl) carbonyl]-L-histidyl-L-prolinamide dehydrate (YM-14673) on spinal reflex potentials and flexor reflexes in spinalized rats

Neuropharmacology
H OnoH Fukuda

Abstract

Experiments were performed on spinalized rats, transected at the Cl level. The intravenous administration of TRH and its analog YM-14673 (N alpha-[(S)-4-oxo-2-azetidinyl) carbonyl]-L-histidyl-L-prolinamide dehydrate) produced marked increases in the amplitude of mono- and polysynaptic reflex potentials and those of the withdrawal flexor reflexes. The effects of YM-14673 were stronger and longer-lasting than those of TRH. The stimulant action of TRH and YM-14673 on the flexor reflexes was not antagonized by prazosin, chlorpromazine, haloperidol or cyproheptadine, suggesting no involvement of the release of catecholamines or serotonin in the stimulant effects of TRH and its analog. Therefore, YM-14673 may be beneficial for the treatment of several spinal motor neuron diseases.

References

Feb 25, 1977·Brain Research·F C KardonR D Utiger
Nov 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·M Yamamoto, M Shimizu
Oct 29, 1981·The New England Journal of Medicine·A I FadenJ W Holaday

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Citations

Aug 27, 1996·Journal of the Autonomic Nervous System·Y KimuraK Kimura
Feb 14, 2006·The Journal of Urology·Hsi-Yang Wu, William C de Groat
Sep 25, 1997·The Journal of Urology·H Kakizaki, W C de Groat
Nov 17, 2009·The Journal of Urology·Yuen-Keng NgChung Kwong Yeung
Nov 20, 2012·The Journal of Urology·Jiasheng ChenKarl-Erik Andersson
Nov 13, 2019·Journal of Peptide Science : an Official Publication of the European Peptide Society·Naotake KobayashiTakayoshi Yoshikawa
Apr 2, 2010·The Journal of the American Academy of Orthopaedic Surgeons·Ranjan GuptaOswald Steward

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