Effects of a new nonionic and a conventional ionic contrast agent on coronary sinus ionized calcium and left ventricular hemodynamics in dogs
Transient myocardial depression associated with intracoronary injections of contrast medium has been attributed to hypertonicity and to calcium binding. To further assess the importance of calcium binding, a new technique for continuous monitoring of coronary sinus ionized calcium with an intravascular calcium-selective electrode was used. With this calcium-selective electrode the effects of intracoronary injection in dogs of a conventional ionic contrast agent, sodium meglumine diatrizoate (Renografin-76), and a new nonionic agent, iohexol, were assessed and compared. Left ventricular pressure was measured with a micromanometer catheter. After bolus injection of 0.2 ml/kg body weight of Renografin-76 (n = 10), coronary sinus pCa increased by 0.27 from 2.98 +/- 0.02 to 3.25 +/- 0.03, indicating a decrease in ionized calcium from 2.0 to 1.1 mEq/liter. With iohexol (n = 9), pCa increased by only 0.05 +/- 0.01 (p less than 0.001), indicating a decrease in ionized calcium from 2.0 to 1.8 mEq/liter. Peak changes occurred approximately 6 seconds after injection. Renografin-76 caused a marked decrease in left ventricular systolic pressure (140 +/- 7 to 106 +/- 8 mm Hg) and in heart rate (122 +/- 7 to 101 +/- 5 beats/min) with an incre...Continue Reading
Cardiovascular effects induced by the injection of a new nonionic contrast medium (Iopamidol): experimental study in dogs
Identification and description of separate mechanisms for two components of renografin cardiotoxicity
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Depression of myocardial contractility induced by hypertonic coronary injections in the isolated perfused dog heart
The influence of hyperosmolality on left ventricular contractile state: disparate effects of nonionic and ionic solutions
Hemodynamic and electrocardiographic effects in man of a new nonionic contrast agent (iohexol): advantages over standard ionic agents
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Regional myocardial hemodynamic and metabolic effects of ionic and nonionic contrast media in normal and ischemic states
Cardiac function during left coronary arteriography in canines with ioxaglate, nonionic compounds, and diatrizoate
Relation between ionized calcium concentration and ventricular pump performance in the dog under hemodynamically controlled conditions
Direct myocardial effects of intracoronary administration of new contrast materials with lost osmolality
A further Contribution regarding the influence of the different Constituents of the Blood on the Contraction of the Heart
Choice of contrast agents for cardiac angiography: review and recommendations based on clinically important distinctions
A multicenter randomized trial of ionic (ioxaglate) and nonionic (iopamidol) low-osmolality contrast agents in cardiac angiography
Mechanism of cardiovascular effects of contrast media: evidence for transient myocardial calcium ion imbalance
Echocardiographic contrast agents: effect of microbubbles and carrier solutions on left ventricular contractility
Iodinated radiographic contrast media inhibit the capacitative calcium entry into smooth muscle cells of the swine renal artery
Cardiac hemodynamic effects of iodixanol, iopamidol, and ioxaglate following left coronary injections in anesthetized dogs
Effects of intravenous isradipine on left ventricular performance during rapid atrial pacing in coronary artery disease
Plasma atrial peptide concentration during acute changes in cardiac filling pressure induced by a contrast agent
Safety, tolerance, and pharmacokinetics of iodixanol injection, a nonionic, isosmolar, hexa-iodinated contrast agent
Comparison of cardiovascular changes after administration of gadodiamide injection and gadopentetate dimeglumine in dogs
A comparison of low- with high-osmolality contrast agents in cardiac angiography. Identification of criteria for selective use
Acute effects of nitric oxide on left ventricular relaxation and diastolic distensibility in humans. Assessment by bicoronary sodium nitroprusside infusion
Iohexol, ioxaglate and iopamidol in coronary angiography. A double-blind comparative study of 300 patients
Is nonionic isotonic iohexol the contrast agent of choice for quantitative myocardial videodensitometry?
Monitoring with In Vivo Electrochemical Sensors: Navigating the Complexities of Blood and Tissue Reactivity.
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