Effects of a new thyrotropin-releasing hormone derivative on behavioral changes after focal cerebral ischemia in rats

Stroke; a Journal of Cerebral Circulation
M YamamotoK Sano

Abstract

We observed the effects of a new thyrotropin-releasing hormone derivative, YM-14673 (N alpha-[[(S)-4-oxo-2-azetidinyl]carbonyl]-L-histidyl-L-prolinamide dihydrate), on behavioral changes in rats for 3 weeks after focal cerebral ischemia. Under halothane anesthesia, the left middle cerebral artery was occluded via a transretro-orbital approach. YM-14673 was administered just after the operation and once a day for 3 weeks. Neurologic deficits, including hemiplegia and abnormal posture, and disturbance of passive avoidance learning were present in solvent-treated control rats for the entire 3 weeks. YM-14673 at 0.1 or 0.3 mg/kg i.p. or 1 mg/kg p.o. significantly accelerated the recovery of neurologic deficits and ameliorated cognitive disturbance compared with the solvent-treated controls although the drug at 0.1 and 0.3 mg/kg i.p. did not influence the size of the ischemic infarct. YM-14673 mitigated the behavioral disturbances in this model of chronic focal cerebral ischemia. We also discuss the suitability of this model for the evaluation of drugs.

References

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Citations

May 16, 1990·European Journal of Pharmacology·M YamamotoM Kobayashi
Jan 12, 1993·European Journal of Pharmacology·F WahlR G Boulu
Dec 1, 1995·Pharmacology, Biochemistry, and Behavior·Y NodaM Oka
Jul 11, 2001·Neuroscience and Biobehavioral Reviews·A C DeVriesP D Hurn
Oct 9, 1998·Journal of Neuroscience Methods·G M de Courten MyersR E Myers
Sep 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F YonemoriA Tamura
Oct 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F YonemoriA Tamura
May 18, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F YonemoriA Tamura
Mar 21, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Devin W McBrideJohn H Zhang
Jan 5, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F YonemoriA Tamura

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