Abstract
We observed the effects of a new thyrotropin-releasing hormone derivative, YM-14673 (N alpha-[[(S)-4-oxo-2-azetidinyl]carbonyl]-L-histidyl-L-prolinamide dihydrate), on behavioral changes in rats for 3 weeks after focal cerebral ischemia. Under halothane anesthesia, the left middle cerebral artery was occluded via a transretro-orbital approach. YM-14673 was administered just after the operation and once a day for 3 weeks. Neurologic deficits, including hemiplegia and abnormal posture, and disturbance of passive avoidance learning were present in solvent-treated control rats for the entire 3 weeks. YM-14673 at 0.1 or 0.3 mg/kg i.p. or 1 mg/kg p.o. significantly accelerated the recovery of neurologic deficits and ameliorated cognitive disturbance compared with the solvent-treated controls although the drug at 0.1 and 0.3 mg/kg i.p. did not influence the size of the ischemic infarct. YM-14673 mitigated the behavioral disturbances in this model of chronic focal cerebral ischemia. We also discuss the suitability of this model for the evaluation of drugs.
References
Nov 1, 1977·Neurology·M D GinsbergJ H Greenberg
Aug 17, 1979·Science·R G Robinson
Nov 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·M Yamamoto, M Shimizu
Jan 1, 1988·Psychopharmacology·M YamamotoA Iwai
Jun 14, 1988·Brain Research·M YamamotoK Sano
Jun 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O GotohG M Teasdale
Mar 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A A MohamedJ McCulloch
Jul 1, 1973·The Journal of Clinical Investigation·R M Bassiri, R D Utiger
Jan 1, 1972·Psychopharmacologia·M Roffman, H Lal
Jan 1, 1972·Progress in Brain Research·A M van der Poel
Jun 1, 1974·Archives of Neurology·M D O'BrienM M Jordan
Aug 1, 1967·Psychological Reports·M E Jarvik, R Kopp
Nov 1, 1983·The International Journal of Neuroscience·M Yasuhara, H Naito
Feb 1, 1984·Journal of Pharmacobio-dynamics·S YokohamaN Kitamori
Aug 1, 1984·Journal of Neurochemistry·K M Schmidt-AchertW K Engel
Nov 15, 1982·Life Sciences·R LevyY Hosobuchi
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A TamuraG M Teasdale
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A TamuraG M Teasdale
Sep 1, 1980·Stroke; a Journal of Cerebral Circulation·A TamuraK Sano
Citations
Jun 8, 1990·European Journal of Pharmacology·M YamamotoH Okamiya
May 16, 1990·European Journal of Pharmacology·M YamamotoM Kobayashi
Jan 3, 1991·European Journal of Pharmacology·M YamamotoM Sasamata
May 17, 1991·European Journal of Pharmacology·M YamamotoK Sano
Jan 12, 1993·European Journal of Pharmacology·F WahlR G Boulu
Mar 21, 1994·European Journal of Pharmacology·K MatsuiS Kwak
Mar 1, 1990·Pharmacology, Biochemistry, and Behavior·M YamamotoY Ozawa
Dec 1, 1995·Pharmacology, Biochemistry, and Behavior·Y NodaM Oka
Jul 11, 2001·Neuroscience and Biobehavioral Reviews·A C DeVriesP D Hurn
Oct 9, 1998·Journal of Neuroscience Methods·G M de Courten MyersR E Myers
Jan 1, 1993·Journal of Neurotrauma·A I Faden
Sep 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F YonemoriA Tamura
Oct 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F YonemoriA Tamura
May 18, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F YonemoriA Tamura
Apr 9, 1993·Brain Research·M YamamotoK Kogure
Mar 21, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Devin W McBrideJohn H Zhang
Jan 5, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F YonemoriA Tamura
Apr 1, 2020·The Journal of Pharmacy and Pharmacology·Yusuke HattoriMakoto Otsuka
Nov 1, 1995·Endocrine Research·T MondenM Mori
Jul 13, 2000·Upsala Journal of Medical Sciences·L O KoskinenJ Svedberg