PMID: 1279732Sep 1, 1992Paper

Effects of a newly synthesized leukotriene antagonist, NZ-107, on immediate-type hypersensitivity reaction in rats and guinea-pigs

Prostaglandins, Leukotrienes, and Essential Fatty Acids
H SudaA Koda

Abstract

The effects of 4-bromo-5-(3-ethoxy-4-methoxybenzylamino)-3(2H)-pyridazinone (NZ-107) on immediate type hypersensitivity reactions in rats and guinea-pigs were studied. 1. When NZ-107, at a dose of 50 mg/kg (i.p.) or 100 mg/kg (orally), was administered to rats, 48-h homologous passive cutaneous anaphylaxis (PCA) reaction and histamine-, leukotriene C4 (LTC4)- and leukotriene D4 (LTD4)-induced skin reactions were suppressed by the agent. 2. NZ-107 (10(-6) g/ml) inhibited both LTC4- and LTD4-induced contractions of isolated rat stomach smooth muscle. 3. NZ-107 inhibited antigen-induced histamine release from rat peritoneal mast cells by 26% at a concentration of 10(-4) g/ml. 4. NZ-107, at doses of 25 and 50 mg/kg (orally), significantly inhibited guinea-pig 3-h heterologous PCA reaction. 5. NZ-107 inhibited antigen-induced histamine release from guinea-pig lung tissue by 17% and 48% at concentrations of 5 x 10(-5) and 10(-4) g/ml, respectively. 6. NZ-107, at doses of 25 and 50 mg/kg (i.p.), inhibited antigen-induced bronchoconstriction and eosinophil accumulation in the bronchoalveolar lavage fluid (BALF) of guinea-pigs. These results suggest that NZ-107 has anti-allergic action including inhibition of eosinophil accumulation in ...Continue Reading

References

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Feb 1, 1991·The Journal of Pharmacy and Pharmacology·A YamamotoS Tanaka
May 1, 1991·Japanese Journal of Pharmacology·A YamamotoS Tanaka
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Citations

Nov 1, 1994·The Journal of Pharmacy and Pharmacology·T AbeH Nagai
Sep 20, 2011·Pharmacology & Therapeutics·Hiroichi Nagai
Feb 12, 2010·Nature·Kelly R TanChristian Lüscher

Related Concepts

4-bromo-5-(3-ethoxy-4-methoxybenzylamino)-3(2H)-pyridazinone
Eosinophilia, Tropical
Cavia porcellus
Histamine Release
Immediate Hypersensitivity
Inotropism
Passive Cutaneous Anaphylaxis
Pyridazines
Bronchoconstriction
Rats, Wistar

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