Effects of a novel cognition-enhancing agent on fetal ethanol-induced learning deficits.

Alcoholism, Clinical and Experimental Research
Daniel D SavageDerek A Hamilton

Abstract

Drinking during pregnancy has been associated with learning disabilities in affected offspring. At present, there are no clinically effective pharmacotherapeutic interventions for these learning deficits. Here, we examined the effects of ABT-239, a histamine H₃ receptor antagonist, on fetal ethanol-induced fear conditioning and spatial memory deficits. Long-Evans rat dams stably consumed a mean of 2.82 g ethanol/kg during a 4-hour period each day during pregnancy. This voluntary drinking pattern produced a mean peak serum ethanol level of 84 mg/dl. Maternal weight gain, litter size and birth weights were not different between the ethanol-consuming and control groups. Female adult offspring from the control and fetal alcohol-exposed (FAE) groups received saline or 1 mg ABT-239/kg 30 minutes prior to fear conditioning training. Three days later, freezing time to the context was significantly reduced in saline-treated FAE rats compared to control. Freezing time in ABT-239-treated FAE rats was not different than that in controls. In the spatial navigation study, adult male offspring received a single injection of saline or ABT-239 30 minutes prior to 12 training trials on a fixed platform version of the Morris Water Task. All rats ...Continue Reading

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Citations

Mar 24, 2010·The Journal of Pharmacology and Experimental Therapeutics·Rafael K VaraschinDaniel D Savage
Mar 9, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Alexandre E Medina
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Apr 16, 2015·Neurotoxicology and Teratology·W M OshiroP J Bushnell
Mar 10, 2012·Trends in Neurosciences·C Fernando ValenzuelaLauren Topper
Aug 7, 2013·Alcoholism, Clinical and Experimental Research·Miranda C StaplesDaniel D Savage
Jun 26, 2015·Alcoholism, Clinical and Experimental Research·Crystal L LantzAlexandre E Medina
Aug 19, 2015·Pharmacology, Biochemistry, and Behavior·Brian C BaculisC Fernando Valenzuela
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Dec 21, 2017·Journal of Neuroinflammation·Joshua J SanchezErin D Milligan
Jan 10, 2018·Alcoholism, Clinical and Experimental Research·Rafael K VaraschinDaniel D Savage
Jul 21, 2021·Biological Psychiatry·Sebastiano Bariselli, David M Lovinger
Sep 23, 2020·Current Biology : CB·Ryan A WirtJames M Hyman

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