Effects of a novel method of anesthesia combining propofol and volatile anesthesia on the incidence of postoperative nausea and vomiting in patients undergoing laparoscopic gynecological surgery

Brazilian Journal of Anesthesiology
Hiroaki KawanoShuzo Oshita

Abstract

We investigated the effects of a novel method of anesthesia combining propofol and volatile anesthesia on the incidence of postoperative nausea and vomiting in patients undergoing laparoscopic gynecological surgery. Patients were randomly divided into three groups: those maintained with sevoflurane (Group S, n=42), propofol (Group P, n=42), or combined propofol and sevoflurane (Group PS, n=42). We assessed complete response (no postoperative nausea and vomiting and no rescue antiemetic use), incidence of nausea and vomiting, nausea severity score, vomiting frequency, rescue antiemetic use, and postoperative pain at 2 and 24h after surgery. The number of patients who exhibited a complete response was greater in Groups P and PS than in Group S at 0-2h (74%, 76% and 43%, respectively, p=0.001) and 0-24h (71%, 76% and 38%, respectively, p<0.0005). The incidence of nausea at 0-2h (Group S=57%, Group P=26% and Group PS=21%, p=0.001) and 0-24h (Group S=62%, Group P=29% and Group PS=21%, p<0.0005) was also significantly different among groups. However, there were no significant differences among groups in the incidence or frequency of vomiting or rescue antiemetic use at 0-24h. Combined propofol and volatile anesthesia during laparosco...Continue Reading

References

Jun 1, 1992·British Journal of Anaesthesia·P G MurphyJ G Jones
Apr 1, 1992·Anesthesia and Analgesia·A BorgeatK Rifat
Jul 1, 1993·Anesthesia and Analgesia·T DiFlorio
Jun 24, 2003·Anesthesia and Analgesia·Tong J GanUNKNOWN Department of Anesthesiology, Duke University Medical Center
Apr 28, 2004·Anesthesiology·Katsuya TanakaDavid C Warltier
Oct 5, 2006·Current Opinion in Anaesthesiology·Bruce T W Allan, Ian Smith
Jun 5, 2010·Journal of Clinical Anesthesia·Elisabetta MaranaRodolfo Proietti

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