PMID: 9167840May 1, 1997Paper

Effects of a novel perfluorocarbon emulsion on neutrophil chemiluminescence in human whole blood in vitro

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
C M EdwardsH Meinert

Abstract

The effects have been studied of a novel perfluorochemical (PFC) emulsion (18.5% perfluorodecalin, 1.5% perfluorodimorpholine propane, 2.5% lecithin) on phorbol 12-myristate 13-acetate (PMA; 100 micrograms ml-1)-induced neutrophil chemiluminescence in citrated human whole blood in vitro. A transient, dose-dependent, decrease in chemiluminescence, to a maximum of 54% after 12 min (P < 0.05), occurred when blood was pre-incubated with 10-40 microliters of the PFC emulsion, compared to saline controls. The mean (+/- s.e.m., n = 6) chemiluminescence of neutrophils incubated with 30 microliters emulsion at 12 min following PMA stimulation (9.5 +/- 1.3 mV) was significantly lower (P < 0.05) than control (24.2 +/- 2.2 mV). Incubation of blood with lecithin up to 16 mg ml-1 and Pluronic F-68 or Pluronic PE 6800 up to 65 mg ml-1 did not affect chemiluminescence.

References

Nov 1, 1992·The Journal of Allergy and Clinical Immunology·C P NielsonM J Connolly
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Citations

May 3, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Norbert KociokAntonia M Joussen
Jul 15, 2003·Tissue Engineering·Kenneth C Lowe
Apr 4, 2000·American Journal of Respiratory Cell and Molecular Biology·S F van EedenP Skippen
Sep 14, 2000·Journal of Colloid and Interface Science·N MureauS Geribaldi
Jun 26, 2001·The Journal of Surgical Research·P McDonaghJ Copeland
Feb 17, 2000·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·K C Lowe
Mar 27, 1999·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·C M EdwardsK C Lowe
Mar 31, 2001·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·S DinkelmannH Northoff

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