PMID: 8594041Nov 1, 1995Paper

Effects of a perfluorocarbon emulsion for enhanced O2 solubility on hemodynamics and O2 transport in dogs

Journal of Applied Physiology
E C JohnsonP D Wagner

Abstract

Perfluorocarbon emulsions raise blood O2 solubility and thus augment O2 transport, but their cardiopulmonary effects at higher doses may limit their use. We therefore examined effects of increasing doses of perfluorooctylbromide emulsion (Oxy) on 1) pulmonary gas exchange, 2) pulmonary and systemic hemodynamics, and 3) mixed venous PO2 (PVO2). After hematocrit reduction to 24-26% by exchange with 5% albumin, anesthetized ventilated dogs breathing 100% O2 were given Oxy (n = 6) or 5% albumin (n = 5) intravenously in four successive 3 ml/kg doses. After each dose, arterial and venous PO2, PCO2, and pH, [O2], hematocrit, heart rate, and systemic, pulmonary arterial, and airway pressures were measured. Ventilation-perfusion relationships and cardiac output (QT) were determined by the multiple inert gas method. Oxy at 12 ml/kg almost doubled blood O2 solubility, increasing arterial [O2] by 1.28 ml/100 ml but did not affect O2 consumption and ventilation-perfusion relationships. QT rose by 21% after 3 ml/kg, then fell with increasing doses (-18% from baseline after 12 ml/kg); O2 delivery remained constant. Oxy at > 6 ml/kg increased systemic blood pressure and systemic vascular resistance considerably. Mean pulmonary arterial pressur...Continue Reading

Citations

Jun 23, 1998·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·D M EckmannJ B Grotberg
Oct 24, 2006·Anesthesia and Analgesia·Kenji YoshitaniG Burkhard Mackensen
Aug 15, 1998·Vox Sanguinis·N S Faithfull, J G Weers
Jun 24, 2009·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Jennifer L H JohnsonEvan C Unger
Jul 15, 1998·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·D M EckmannJ B Grotberg
Aug 24, 2013·Biotechnology Progress·Daniel OrtizJuan C Briceño
Jul 29, 2011·The Journal of Physical Chemistry. B·Christopher A FrakerCherie L Stabler

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