PMID: 8426911Jan 22, 1993Paper

Effects of a physiological dose of cholecystokinin on food intake and postprandial satiation in man

Regulatory Peptides
R J LieverseC B Lamers

Abstract

CCK-33 was infused intravenously to groups of 9 lean and 9 obese volunteers in doses that elicited plasma CCK concentrations in the physiological range. The effect of these infusions on food intake and satiety signals was compared with the effect of saline infusions in the same subjects. Food intake (486 +/- 52 g; mean +/- S.E.M.) was slightly, but not significantly decreased (553 +/- 55 g after saline), and hunger and fullness feelings after eating were unaffected, in both of the two groups. We conclude that the infusion of CCK-33 to plasma levels comparable to those observed after a fatty meal does not have a major effect on food intake and postprandial hunger feelings.

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Citations

Jun 1, 1997·Journal of Clinical Pharmacology·M WeiserM A Abdeen
Sep 17, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A ColecchiaD Festi
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Jul 4, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Owais ChaudhriSteve Bloom
Mar 23, 1994·Annals of the New York Academy of Sciences·R J LieverseC B Lamers
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Jul 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J P GutzwillerC Beglinger

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