Effects of a potent and specific beta 2-adrenoceptor antagonist on intraocular pressure

British Journal of Pharmacology
J A Nathanson

Abstract

1 Physiological studies support the possibility of adrenergic regulation of aqueous humor secretion from the ciliary process, a tissue which has recently been shown to contain a predominance of beta 2-adrenoceptors. 2 The present experiments examine the effects of a potent and highly specific beta 2-antagonist (IPS 339) on intraocular pressure in the normal rabbit eye. 3 The observed decrease in pressure caused by IPS 339 suggests that highly specific beta 2-antagonists may be useful in decreasing elevated intraocular pressure.

Citations

Jan 1, 1984·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C J SchmittN N Share
Jan 1, 1989·Pharmacology & Therapeutics·M F Sugrue
Dec 1, 1982·The British Journal of Ophthalmology·G E Trope, B Clark
Aug 1, 1983·The British Journal of Ophthalmology·A Rushton
Jun 1, 1987·The British Journal of Ophthalmology·R G DevenyiW H Hunter
Jan 1, 1982·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·H C Innemee, P A van Zwieten
Oct 3, 2003·Expert Opinion on Pharmacotherapy·Ciro CostagliolaAdolfo Sebastiani
Apr 1, 1986·The Journal of Pharmacy and Pharmacology·M AlkondonP Sen
Nov 1, 1988·The Journal of Pharmacy and Pharmacology·J A Nathanson, E J Hunnicutt

Related Concepts

IPS 339, monohydrochloride, (+-)-isomer
Adrenergic beta-Antagonists
Metazoa
Physiologic Intraocular Pressure
Propanolamines
Chinchilla Rabbits

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