Effects of a primary immune response to T-cell dependent antigen on serotonin metabolism in frontal cortex: in vivo microdialysis study in freely moving Fischer 344 rat

Brain Research
A M GardierM J Pallardy

Abstract

Antigenic challenge is known to influence brain catecholamine turnover, e.g. hypothalamic norepinephrine activity, but little is known about effects on the activity of serotoninergic neurons, i.e. the release of the neurotransmitter at nerve terminals. In the present study, we first investigated the changes of central serotonin (5-HT) metabolism in Fischer 344 male rats at 2, 3, 4 and 5 days following i.v. immunization with sheep red blood cell (SRBC). Major decreases in 5-HT levels were evident in the hypothalamus (Hy) and cortex (Cx) at a time which corresponded to the late phase of the production of specific antibodies to SRBC measured with a plaque-forming cell assay (PFC). A pretreatment with an immunosuppressive drug, cyclosporin A (CsA; 12.5 mg/kg by gavage for 7 days) prevented the decreases in cortical 5-HT levels. Concomitantly, a 2-fold increase in the basal 5-HT release at frontocortical nerve terminals was observed by using in vivo microdialysis in awake rats on Day 3 following SRBC inoculation. This effect was totally suppressed by CsA. Our data suggest that the decrease in brain 5-HT levels that occurs after antigen administration may reflect a specific short-lasting CsA-dependent-release of 5-HT at frontocortica...Continue Reading

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Citations

May 30, 2015·Neuroscience and Biobehavioral Reviews·Preeti JaiswalUsha Rajamma
Mar 19, 1999·Brain, Behavior, and Immunity·R Mössner, K P Lesch
Jun 30, 1998·American Journal of Reproductive Immunology : AJRI·Y DanielJ B Lessing
Nov 29, 2013·Photodermatology, Photoimmunology & Photomedicine·Suzanne M PilkingtonLesley E Rhodes
Jul 31, 1998·Immunology and Cell Biology·J Kovarik, C A Siegrist
Nov 14, 1997·American Journal of Reproductive Immunology : AJRI·R MaityL M Nelson
Aug 12, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K YanaiT Watanabe

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