Effects of a psychostimulant drug sydnocarb on rat brain dopaminergic transmission in vivo

European Journal of Pharmacology
R R GainetdinovK S Rayevsky

Abstract

Transcerebral microdialysis was used to evaluate the effect of a psychostimulant drug, sydnocarb (3-(beta-phenylisopropyl)-N-phenylcarbamoylsydnonimine), on the extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the dorsal striatum and nucleus accumbens of freely moving rats. Sydnocarb dose dependently (4.4, 8.75 and 17.5 mg/kg, i.p.) induced a relatively modest (up to 350% of control) and long-lasting (up to 6 h) increase in dopamine extracellular level in the rat dorsal striatum. The drug at 8.75 mg/kg, i.p., produced an approximately similar increase in dopamine efflux in the dorsal striatum and in the nucleus accumbens of freely moving rats. Sydnocarb had no effect on DOPAC or HVA extracellular levels in the rat basal ganglia in vivo at any dose studied. It is important that the drug increased the efflux of dopamine in a tetrodotoxin-sensitive and Ca2+-dependent manner. Measurements of behavioral parameters in non-operated rats revealed that sydnocarb markedly increased locomotor activity and induced stereotyped behavior. These data suggest that the stimulant action of sydnocarb is accompanied by a facilitation of central dopaminergic transmission involving an increase in...Continue Reading

References

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Citations

Sep 12, 2013·Cell and Tissue Research·Elmira Anderzhanova, Carsten T Wotjak
Aug 18, 2001·Pharmacology, Biochemistry, and Behavior·I I Afanas'evK S Rayevsky
Aug 12, 2014·Behavioural Brain Research·Rodrigo Moraga-AmaroJimmy Stehberg
Apr 3, 2009·Archiv der Pharmazie·Mikko VahermoJari Yli-Kauhaluoma
Feb 9, 2011·The Journal of Pharmacology and Experimental Therapeutics·John A GrunerMaciej Gasior
Apr 29, 2020·AIMS Neuroscience·Valentina Bashkatova, Athineos Philippu

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