Effects of a putative antidepressant with a rapid onset of action in defeated mice with different coping strategies

Progress in Neuro-psychopharmacology & Biological Psychiatry
Eneritz Gómez-LázaroA Arregi

Abstract

There is evidence suggesting that stressful social events may result in depressive-like disorders, but the development of these disorders depend on the way in which people cope with stress. Although antidepressants are useful their drawback is a delay in the therapeutic effects, moreover not all the patients show an adequate response to this treatment. The aim of this study was to analyse the effect of RS 67333, which is a 5-HT(4) receptor partial agonist and a putative antidepressant which exhibits a rapid onset of action and to determine whether this drug reverses the behavioural and physiological effects that are generated by chronic defeat in subjects who manifest a more vulnerable profile in their response to stress. Male mice were exposed to defeat for 21 consecutive days using a sensorial contact model. After 18 days of defeat, 2 groups of subjects were established, active and passive, in accordance with the behaviour that was manifested during social confrontation, and drug treatment was initiated for 5 days. Finally, the animals were subjected to a forced swimming test (FST). The results revealed higher corticosterone levels in passive mice after the last defeat. Additionally, 3 days after the last defeat, they showed ...Continue Reading

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Citations

Aug 27, 2014·Proceedings of the National Academy of Sciences of the United States of America·Cédric LecouteyPatrick Dallemagne
Apr 29, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Li CaiTing-ni Wu
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Jun 15, 2020·Brain Research Bulletin·Qin WuJihu Sun

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