Effects of a recruitment maneuver on plasma levels of soluble RAGE in patients with diffuse acute respiratory distress syndrome: a prospective randomized crossover study

Intensive Care Medicine
Matthieu JabaudonJean-Michel Constantin

Abstract

The soluble form of the receptor for advanced glycation end-products (sRAGE) is a promising marker for epithelial dysfunction, but it has not been fully characterized as a biomarker of acute respiratory distress syndrome (ARDS). Whether sRAGE could inform on the response to ventilator settings has been poorly investigated, and whether a recruitment maneuver (RM) may influence plasma sRAGE remains unknown. Twenty-four patients with moderate/severe, nonfocal ARDS were enrolled in this prospective monocentric crossover study and randomized into a "RM-SHAM" group when a 6-h-long RM sequence preceded a 6-h-long sham evaluation period, or a "SHAM-RM" group (inverted sequences). Protective ventilation was applied, and RM consisted of the application of 40 cmH2O airway pressure for 40 s. Arterial blood was sampled for gas analyses and sRAGE measurements, 5 min pre-RM (or 40-s-long sham period), 5, 30 min, 1, 4, and 6 h after the RM (or 40-s-long sham period). Mean PaO2/FiO2, tidal volume, PEEP, and plateau pressure were 125 mmHg, 6.8 ml/kg (ideal body weight), and 13 and 26 cmH2O, respectively. Median baseline plasma sRAGE levels were 3,232 pg/ml. RM induced a significant decrease in sRAGE (-1,598 ± 859 pg/ml) in 1 h (p = 0.043). At 4 ...Continue Reading

References

Dec 1, 1990·The American Review of Respiratory Disease·M A Matthay, J P Wiener-Kronish
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
May 4, 2000·The New England Journal of Medicine·L B Ware, M A Matthay
Dec 8, 2000·Biochimica Et Biophysica Acta·A M SchmidtD M Stern
Oct 3, 2001·The Journal of Clinical Investigation·A M SchmidtD M Stern
Mar 29, 2003·American Journal of Respiratory and Critical Care Medicine·Michael A MatthayAndrea L Harabin
Oct 22, 2003·Intensive Care Medicine·Christian Brun-BuissonUNKNOWN ALIVE Study Group
Mar 11, 2004·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Madoka ShirasawaYutaka Hata
Sep 1, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Angelika BierhausPeter P Nawroth
Feb 4, 2006·American Journal of Respiratory and Critical Care Medicine·Tokujiro UchidaMichael A Matthay
Apr 18, 2008·Critical Care : the Official Journal of the Critical Care Forum·Jean-Michel ConstantinJean-Etienne Bazin
Jul 8, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Angela RaucciMarco E Bianchi
Oct 28, 2009·Chest·Lorraine B WareUNKNOWN NHLBI ARDS Clinical Trials Network
Mar 18, 2010·Anesthesiology·Patrick RayTim T Houle
Apr 30, 2010·Critical Care : the Official Journal of the Critical Care Forum·Jean-Michel ConstantinJean-Etienne Bazin
Jun 16, 2010·Critical Care : the Official Journal of the Critical Care Forum·Pedro L SilvaPatricia R M Rocco
Sep 17, 2010·The New England Journal of Medicine·Laurent PapazianUNKNOWN ACURASYS Study Investigators
Feb 8, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anja H HergrueterCaroline A Owen
Jan 17, 2012·Current Opinion in Anaesthesiology·Luciano GattinoniThomas Langer
Jan 31, 2013·Intensive Care Medicine·R P DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
May 22, 2013·The New England Journal of Medicine·Claude GuérinUNKNOWN PROSEVA Study Group
Oct 26, 2013·Critical Care Medicine·Matty L TerpstraA B Johan Groeneveld
Dec 5, 2014·Intensive Care Medicine·Gerard F Curley, John G Laffey

❮ Previous
Next ❯

Citations

Mar 17, 2016·Disease Markers·Raiko BlondonnetMatthieu Jabaudon
Jan 30, 2016·Intensive Care Medicine·Armand Mekontso DessapSean M Bagshaw
Jul 1, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Matthieu JabaudonJean-Michel Constantin
Aug 21, 2015·Intensive Care Medicine·Erica Aranha SuzumuraAlexandre Biasi Cavalcanti
Aug 2, 2016·Chest·Gerard F CurleyArthur S Slutsky
May 17, 2017·Hospital Practice·Oleg Epelbaum, Wilbert S Aronow
Feb 10, 2018·Scientific Reports·Matthieu JabaudonJean-Michel Constantin
Sep 10, 2020·Anesthesiology·David LagierMarie-Christine Alessi
Aug 30, 2020·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Hawa EdrissKenneth Nugent
Aug 6, 2017·Intensive Care Medicine·Ary Serpa NetoLaurent Papazian
Aug 25, 2018·Intensive Care Medicine·Benjamin Coiffard, Laurent Papazian
Dec 6, 2020·Current Opinion in Critical Care·Matthieu JabaudonLorraine B Ware
Jun 3, 2021·Journal of Clinical Medicine·Matthieu Jabaudon On Behalf Of The Live Study Group And The Azurea Network

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.