Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving

Human Psychopharmacology
Manabu TashiroKazuhiko Yanai

Abstract

The sedative side effects of antihistamines have been recognized to be potentially dangerous in car driving, but the mechanism underlying these effects has not yet been elucidated to date. The aim of the present study is to examine regional cerebral blood flow (rCBF) responses during a simulated car-driving task following oral administration of D-chlorpheniramine using positron emission tomography (PET) and [15O]H2O, based on a single-blind cross-over study-design. Right-handed, healthy male volunteers (n = 14) drove a car in a simulated environment following oral administration of D-chlorpheniramine repetab 6 mg or placebo. Their rCBF was measured using PET with [15O]H2O in the following three conditions: (1) resting, (2) active driving, and (3) passive driving. All 'in-car' views during the simulated driving were videotaped and used for rating driving performance. Performance evaluation revealed that the number of lane deviations significantly increased in the D-chlorpheniramine condition compared with the placebo condition (p < 0.01). Subjective sleepiness was not significantly different between the two drug conditions. The regions of diminished brain responses following D-chlorpheniramine treatment were detected in the pari...Continue Reading

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Citations

Aug 21, 2013·Experimental Brain Research·Yasuhiro ChiharaShinichi Iwasaki
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Feb 28, 2014·International Psychogeriatrics·Jianfang ChangLinda Chiu Wa Lam
Aug 4, 2010·International Psychogeriatrics·Ivan AprahamianMônica Sanches Yassuda
Mar 27, 2021·Accident; Analysis and Prevention·Milad HaghaniHamish MacDougall

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