Effects of a short-acting [beta]1 receptor antagonist landiolol on hemodynamics and tissue injury markers in patients with subarachnoid hemorrhage undergoing intracranial aneurysm surgery

Journal of Neurosurgical Anesthesiology
Masahiko KawaguchiIntraoperative Landiolol for Intracranial Aneurysm Surgery Trial (ILAST) Investigators

Abstract

Sympathetic activation after subarachnoid hemorrhage (SAH) can induce tachycardia as well as cardiac and brain injury. We examined the effects of beta1 receptor antagonist landiolol on hemodynamics and the levels of tissue injury markers in patients with SAH. Fifty-six SAH patients undergoing intracranial aneurysm surgery with tachycardia (>or=90 beats per minute) randomly allocated to landiolol (L) or control (C) group were examined. In L group, landiolol was continuously administered during anesthesia. In C group, landiolol was not administered except bolus dose used in cases that exhibited uncontrolled tachycardia. Hemodynamics, the incidence of electrocardiographic abnormality, and levels of B-type natriuretic peptide, troponin T, S-100beta, 8-Hydroxy-2'-deoxyguanosine, interleukin-6 (IL-6), and IL-1 receptor antagonist were compared. Heart rate values from time of intubation to the end of anesthesia were significantly lower in L group than in C group, whereas blood pressure was similar between the groups. Although the incidence of bradycardia (<60 beats per minute) was significantly higher in L group than in C group (57% vs. 18%, respectively), bradycardia could be recovered without any adverse effects. The serum S-100beta...Continue Reading

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Citations

Mar 11, 2011·Journal of Neurosurgical Anesthesiology·Jeffrey J Pasternak, William L Lanier
Jan 22, 2015·Future Cardiology·Sowmya PinnamaneniWilbert S Aronow
Mar 14, 2018·The Cochrane Database of Systematic Reviews·Hermann BlessbergerClemens Steinwender
Sep 19, 2014·The Cochrane Database of Systematic Reviews·Hermann BlessbergerClemens Steinwender
Sep 27, 2019·The Cochrane Database of Systematic Reviews·Hermann BlessbergerClemens Steinwender
Jan 30, 2020·Neurocritical Care·Aravind V RameshMatt Thomas

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