Effects of a single-dose hypertonic saline hydroxyethyl starch on cerebral blood flow, long-term outcome, neurogenesis, and neuronal survival after cardiac arrest and cardiopulmonary resuscitation in rats*

Critical Care Medicine
Rüdiger R NoppensOliver Kempski

Abstract

The beneficial effects of hypertonic saline on neuronal survival and on cerebral blood flow have been shown in several animal models of global and focal brain ischemia. Because of the potential benefits of hypertonic solutions, it is hypothesized that hydroxyethyl starch enhances cerebral blood flow and improves long-term outcome after cardiac arrest and cardiopulmonary resuscitation in an animal model. Laboratory animal study. University animal research laboratory. Fifty-nine male Sprague-Dawley rats. Rats were randomized to receive either 7.2% saline/6% hypertonic saline hydroxyethyl starch (4 mL/kg) or vehicle (NaCl 0.9 %) after 9 mins of asphyxic cardiac arrest and cardiopulmonary resuscitation. Local cerebral blood flow and physiologic parameters were evaluated during arrest and early restoration of spontaneous circulation. Survival and neurologic assessment were evaluated over a 7-day observation period. Animals received 5-bromo-2-deoxyuridine for 6 days. Neuronal injury and neurogeneration (5-bromo-2-deoxyuridine positive neurons) were quantified on day 7 after cardiac arrest and cardiopulmonary resuscitation. Hypertonic saline hydroxyethyl starch treatment resulted in an accentuated local cerebral blood flow during earl...Continue Reading

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Citations

Sep 26, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Qian Zhang, Chunsheng Li
Jun 20, 2012·Critical Care Medicine·Michael Fries
Dec 15, 2015·Critical Care : the Official Journal of the Critical Care Forum·Chun-Yu WuUNKNOWN NTUH Center of Microcirculation Medical Research
Dec 8, 2004·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ruediger Noppens, Ansgar M Brambrink
Jul 22, 2021·Circulation Research·Ryan L HoilandMypinder S Sekhon
Sep 3, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Guanghui ZhengWanchun Tang

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