Effects of a synthesized phosphodiesterase inhibitor, ZSY-27, on pancreatic exocrine secretion of the dog

Clinical and Experimental Pharmacology & Physiology
K IwatsukiS Chiba

Abstract

The effects of a synthesized phosphodiesterase inhibitor, ZSY-27, on the secretion of pancreatic juice were investigated in dog isolated and blood-perfused pancreas, and compared with those of secretin and dopamine. Intravenous administration of ZSY-27 (0.3-1 mg/kg) elicited increases in pancreatic secretion. Intra-arterial (i.a.) administration of ZSY-27 (0.1-1 mg) also elicited increased secretion. The secretory activity of ZSY-27 (1 mg) was approximately equal to that of 0.1 units of secretin and 2.5 micrograms of dopamine. The concentration of bicarbonate in the pancreatic juice induced by ZSY-27 i.a. was increased, but the protein concentration was not increased significantly. These effects are analogous to those of secretin and dopamine. ZSY-27-induced pancreatic secretion was not modified by pretreatment with phentolamine, propranolol, atropine, sulpiride and cimetidine. Secretin-induced secretion was significantly potentiated by infusion of ZSY-27 (25 micrograms/min) but dopamine-induced one was not. These results suggest that ZSY-27 increases pancreatic secretion acting directly on the ductular cells of the dog pancreas, at least in part, through the increase of intracellular cyclic AMP concentration by inhibiting phos...Continue Reading

References

Jan 1, 1977·Annual Review of Pharmacology and Toxicology·B Weiss, W N Hait
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Jan 1, 1973·The American Journal of Physiology·P R BieckR B Adkins
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Dec 1, 1971·British Journal of Pharmacology·K HashimotoO Takeuchi
Apr 8, 1982·European Journal of Pharmacology·K IwatsukiS Chiba
Jan 1, 1981·Scandinavian Journal of Gastroenterology·M V SingerM I Grossman

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