Effects of ABCA1 variants on rosiglitazone monotherapy in newly diagnosed type 2 diabetes patients

Acta Pharmacologica Sinica
Jie WangKun-san Xiang

Abstract

The aim of the present study was to investigate the relationship between R219K, M883I, and R1587K variants of the ATP-binding cassette transporter subfamily A number 1 (ABCA1) gene and response to rosiglitazone treatment in newly diagnosed patients with type 2 diabetes. A total of 105 diabetic patients with no history of antihyperglycemia medication were treated with rosiglitazone (4 or 8 mg daily) for 48 weeks. Three non-synonymous variants R219K, M883I, and R1587K, were genotyped in all patients. Ninety-three patients completed the entire study. The R219K variant of ABCA1 had an effect on rosiglitazone response with the per-allele odds ratio of 2.04 for treatment failure (P<0.05). The RR homozygotes had a better improvement in indicators of insulin sensitivity, as determined by a significantly greater decrease in the homeostasis model assessment index of insulin resistance (-2.39+/-0.46 vs -0.69+/-0.51, P<0.05). No genotype-phenotype association was detected for M883I and R1587K. The R219K variant of ABCA1 was associated with the therapeutic effect of rosiglitazone. The RR homozygotes had a better response to rosiglitazone treatment in terms of insulin sensitivity improvement than minor K allele carriers. Neither the M883I no...Continue Reading

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Mar 28, 2009·Current Diabetes Reports·Ewan R Pearson
Apr 15, 2011·Lipids in Health and Disease·Vana KolovouConstantinos A Demopoulos
Jul 12, 2012·Journal of Diabetes·Weihui YuWeiping Jia
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Aug 2, 2018·Frontiers in Pharmacology·Marina Kawaguchi-SuzukiReginald F Frye

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