PMID: 3906227Sep 1, 1985

Effects of acetate and bicarbonate dialysate in stable chronic dialysis patients

Kidney International
R M HakimM N Gottlieb

Abstract

The effects of acetate and bicarbonate dialysate on the biochemical and clinical parameters of 16 stable chronic hemodialysis patients were investigated in a double-blind crossover study. A central delivery system was used for both types of dialysates with identical sodium concentrations (138 mEq/liter) and osmolality in a single-pass dialysate flow. The results indicate that dialysis with bicarbonate leads to significantly less hypoxemia (P less than or equal to 0.001) and hypotensive episodes (P less than or equal to 0.002) than with acetate. Pre- to post-dialysis blood pressure changes were also more marked during acetate dialysis. Older patients with recurrent hypotension on acetate benefit most from bicarbonate dialysate. This group of patients appears to metabolize acetate more slowly and has a significantly lower post-dialysis bicarbonate concentration (P less than or equal to 0.005) than asymptomatic patients during dialysis with acetate dialysate.

References

Mar 1, 1978·Annals of Internal Medicine·U GraefeB H Scribner
Jun 1, 1979·Kidney International·K J Wingert, M W Weiner
Sep 1, 1979·The Journal of Clinical Investigation·C L SkutchesG A Reichard
Jan 1, 1979·Nephron·G F GuarnieriL Campanacci
Jan 1, 1978·Journal of Dialysis·Y AizawaY Hirasawa
Nov 1, 1982·Artificial Organs·H HamplM Kessel
Jul 1, 1982·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R H RichardsM W Weiner
Mar 1, 1982·Kidney International·M D PagelB H Scribner
Dec 1, 1982·Kidney International·J L VincentR J Kahn
Nov 1, 1982·Artificial Organs·R A Ward, R L Wathen

Citations

Oct 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·D M FordG M Lum
May 1, 1987·Medical & Biological Engineering & Computing·J S WilkinsonC Aldridge
Jan 1, 1988·Advances in Enzyme Regulation·R L Veech, W L Gitomer
Jun 8, 2001·European Journal of Internal Medicine·W J. Mulder, H F.P. Hillen
Nov 24, 1999·Kidney International. Supplement·P HeeringB Grabensee
Feb 1, 1989·Artificial Organs·U BaurmeisterA Luttrell
Jan 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R A ShermanR P Cody
Feb 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R M Hakim, N Levin
Nov 1, 1988·Kidney International·R L Veech
Feb 1, 1991·Kidney International·J T Daugirdas
Oct 1, 1994·Kidney International·T Alp IkizlerR M Hakim
Apr 1, 1992·Kidney International·T SymrengV S Lim
Feb 1, 1990·Kidney International·R M Hakim
Oct 29, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T Alp Ikizler, Gerald Schulman
Jan 25, 2005·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Terumi HiguchiKoichi Matsumoto
May 15, 2007·Nephrology·Tsun G NgCarmel M Hawley
Oct 7, 2011·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Shoichiro DaimonMitsuhiro Kawano
Jan 24, 2014·Seminars in Dialysis·Finnian R Mc Causland, Sushrut S Waikar
May 20, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jair Munoz MendozaBrigitte Schiller
Sep 18, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Jan 18, 2006·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Yoichi ShimadaAtsuhiro Sakamoto
Jul 15, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Philippe ChauveauChristian Combe
Aug 3, 2000·Seminars in Dialysis·F J Gennari
Nov 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L E AndersonW L Henrich
Oct 4, 2018·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Matthew E CoveJohn A Kellum
Oct 21, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·R ChodockJ D Rich
Jan 10, 2017·Seminars in Dialysis·Rita L McGill, Daniel E Weiner
Apr 3, 2019·Seminars in Dialysis·Jaime Uribarri, Man S Oh
Jan 9, 2021·The Journal of Pharmacology and Experimental Therapeutics·Brian G PollJennifer L Pluznick

Related Concepts

Acetic Acids
Carbonic Acid Ions
Clinical Trials
Double-Blind Method
Hemodialysis
Hypotension
Vinegar

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.