Effects of acetate and other short-chain fatty acids on sugar and amino acid uptake of Bacillus subtilis.

Journal of Bacteriology
C W SheuE Freese

Abstract

Acetate and other short chain n-fatty acids (C(1)-C(6)) inhibit strongly the uptake of l-serine or other l-amino acids but inhibit only weakly that of alpha-methylglucoside or fructose, whether measured in whole cells of Bacillus subtilis or in membrane vesicles that have been energized with reduced nicotinamide adenine dinucleotide (NADH), l-alpha-glycerol phosphate, or ascorbate plus phenazine methosulfate. The acetate inhibition is noncompetitive, as was shown for l-alpha-aminoisobutyric acid uptake by whole cells and for l-serine uptake by membrane vesicles. In membrane preparations, neither NADH oxidation nor the reduction of cytochromes by NADH are affected by fatty acids. All of these effects are similar to those of 2, 4-dinitrophenol. It is concluded that the fatty acids "uncouple" the amino acid carrier proteins from the cytochrome-linked electron transport system (to which they may be coupled via protein interaction or via a cation gradient).

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Citations

Oct 1, 1996·Oral Microbiology and Immunology·S Shapiro
Sep 1, 1992·Food Additives and Contaminants·E Quattrucci, V Masci
Jun 1, 1996·Letters in Applied Microbiology·J L Thompson, M Hinton
Nov 1, 2007·Journal of Food Protection·Kathleen A GlassKristine L Zierke
Jul 1, 2009·Comprehensive Reviews in Food Science and Food Safety·Rosa M Raybaudi-MassiliaOlga Martín-Belloso
Apr 30, 2020·Archives of Medical Research·Undurti N Das
Aug 1, 1977·Infection and Immunity·R D MillerS A Morse
Jul 1, 1973·Journal of Bacteriology·G A Marzluf
Mar 1, 1975·Antimicrobial Agents and Chemotherapy·C W SheuE Freese
Nov 1, 1985·Journal of Bacteriology·S E GeorgeT Melton
Feb 1, 1976·Applied and Environmental Microbiology·J P Fay, R N Farías
Sep 1, 1977·Antimicrobial Agents and Chemotherapy·B C Levin, E Freese
Dec 1, 1975·Bacteriological Reviews·H L Sadoff
Apr 1, 1974·Journal of Bacteriology·Y Murooka, T Harada

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