PMID: 8608436Mar 1, 1995Paper

Effects of acetazolamide on the sleep apnea syndrome and its therapeutic mechanism

Psychiatry and Clinical Neurosciences
T SakamotoT Kotorii

Abstract

Twenty male patients with sleep apnea syndrome were treated with acetazolamide (AZM), a carbonic anhydrase inhibitor. In 14 of the patient a significant decrease was found in the number of apnea, apnea index and % apnea time (percentage of time spent with apnea to the total sleep time) with improvement in sleep structure, clinical symptoms, such as insomnia, daytime excessive sleepiness and snoring. A significant decrease was also observed in arterial blood pH and HCO-3 in the 14 improved patients. On the other hand, no improvement occurred in the parameters of sleep apnea and sleep with AZM in the remaining six patients. Moreover, metabolic acidosis and an improvement in arterial blood gases did not occur with AZM in the six patients.

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Citations

Mar 26, 2011·Journal of Applied Physiology·Andrew WellmanDavid P White
Apr 9, 2004·American Journal of Respiratory and Critical Care Medicine·Lyle J PalmerSusan Redline
Jan 6, 2012·The Journal of Physiology·Bradley A EdwardsAndrew Wellman
Mar 20, 2012·Expert Opinion on Pharmacotherapy·Chia Mo LinChristian Guilleminault
Aug 25, 1999·Psychiatry and Clinical Neurosciences·Y InoueR Kawahara
Apr 26, 2020·BMJ Open Respiratory Research·Christopher N SchmicklAtul Malhotra
Apr 20, 2013·Journal of Applied Physiology·Ailiang XieJerome A Dempsey
Feb 5, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Yue-Nan NiRobert Joseph Thomas
Jan 25, 2021·Sleep Medicine Clinics·Simon A JoostenBradley A Edwards

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