PMID: 9533615Apr 9, 1998Paper

Effects of acetylcholine and nitroprusside on systemic and regional hemodynamics in hypertensive rats

Clinical and Experimental Hypertension : CHE
S O GranstamL Lind

Abstract

This study was performed to investigate the in vivo effects of acetylcholine, a stimulator of endogenous NO production, and nitroprusside, an exogenous NO-donor, on hemodynamics in the normotensive (WKY) and the hypertensive (SHR) rat. Anesthetized rats were given microspheres for the measurement of cardiac index (CI), total vascular resistance (TPRI), regional blood flow and vascular resistance. Infusion of acetylcholine (2 microg/kg/min) caused a marked decrease in TPRI by (-35+/-5%, +/-SEM) in the WKY (n=8), whereas in the SHR (n=8) a less pronounced reduction was seen (-14+/-3%, p<0.01 between groups). CI increased by 27+/-9% in the WKY, but was unaltered in the SHR. Blood pressure decreased similarly (17-20%). Acetylcholine significantly increased blood flow by about 40% in the kidneys and the heart in the WKY, but had no significant effect in the SHR. Other tissues, such as skeletal muscle and cerebral tissues, showed no major changes. Infusion of nitroprusside (1 microg/kg/min) reduced blood pressure by 5 to 10% in the strains. The regional effects of nitroprusside did not differ between the strains. In conclusion, the acetylcholine-induced vasodilation in the kidney and the heart was attenuated in the SHR compared to th...Continue Reading

References

Sep 1, 1992·European Heart Journal·M VogtB E Strauer
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Citations

Sep 29, 1998·Clinical and Experimental Pharmacology & Physiology·S O GranstamB Fellström
Jun 4, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M GerováM Cebová
Nov 15, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Isabelle IltisMonique Bernard
Mar 30, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Ramesh C MishraVenkat Gopalakrishnan
Jul 11, 2012·Medicine and Science in Sports and Exercise·Isabelle MasseauDouglas K Bowles
Oct 11, 2001·Journal of Hypertension·B von zur MühlenL Lind
Aug 7, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A S KhanW E Sonntag
Jan 16, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Masahito KajiyaFumihiko Kajiya

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