Aug 1, 1976

Effects of acidity, cations and alcoholic fractionation on absorption of heparin from gastrointestinal tract

Canadian Journal of Physiology and Pharmacology
T K SueE Yuen


Heparin was introduced into the stomach or duodenum of mice separately in doses of ca. 250 mg/kg. A slight anticoagulant effect in the systemic circulation was detected in whole blood clotting times and factor X inhibition. In contrast to most drugs, more heparin was absorbed from the stomach than from the intestine. Suppressing ionization of heparin by simultaneous administration of acid resulted in improved absorption of heparin from the small intestine. Heparin was separated with ethanol into five molecular weight fraction: I, 17 999; II, 13 i99; III, 10800, IV, 8 700; and V, 6 700. Each was introduced into the duodenum of mice with citric acid. The maximum hypocoagulability was produced with fraction IV. When administered in distilled water instead of in citric acid, this heparin fraction did not produce an anticoagulant effect. These studies demonstrated that improvement of heparin absorption from the gastrointestinal tract can be obtained by the combination of suppressing ionization and selecting molecular size.

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Mentioned in this Paper

Ethanol Measurement
Citricum acidum, citric acid, homeopathic preparation
Entire Gastrointestinal Tract
Small Intestinal Wall Tissue
Distilled water

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