Effects of activated macrophages on Nacardia asteroides.

Infection and Immunity
G A FiliceJ S Remington

Abstract

The mechanism(s) of host resistance against Nocardia asteroides has not been well defined. Since disease due to N. asteroides frequently occurs in patients with impaired cell-mediated immunity, we studied the interaction of N. asteroides with activated and control mouse peritoneal macrophages. Activated macrophages were from mice infected with Toxoplasma gondii or injected with Corynebacterium parvum. N. asteroides in the early stationary phase (>99% in the coccobacillary form) was used for challenge of macrophage monolayers. Growth of two strains of N. asteroides was markedly inhibited in activated macrophages, whereas N. asteroides grew well in control macrophages. Quantitation of macrophage-associated N. asteroides indicated that activated macrophages killed 40 to 50% of N. asteroides within 6 h (P < 0.002). In control macrophage preparations, it appeared as if Nocardia filaments extended from within macrophages to the outside, and many of these filaments appeared to have extended to and then grown through neighboring macrophages. In activated macrophage preparations, Nocardia remained in the coccobacillary form in most macrophages. Control macrophage monolayers were almost completely overgrown with and destroyed by Nocardia...Continue Reading

References

Mar 23, 1978·The New England Journal of Medicine·B M Babior
Nov 1, 1977·Cellular Immunology·R McLeod, J S Remington
Feb 1, 1977·Infection and Immunity·T Sundararaj, S C Agarwal
Jun 1, 1977·Infection and Immunity·B L Beaman, S Maslan
Nov 1, 1977·The American Journal of Tropical Medicine and Hygiene·R McLeod, J S Remington
Apr 1, 1978·Infection and Immunity·B L Beaman, S Maslan
Apr 1, 1976·Infection and Immunity·B L Beaman, M Smathers
Sep 1, 1976·The Journal of Infectious Diseases·B L BeamanW Causey
Jan 1, 1975·Annals of Internal Medicine·J A KrickJ S Remington
Jun 1, 1975·The Journal of Infectious Diseases·J A Krick, J S Remington
Aug 1, 1976·Cellular Immunology·J L KrahenbuhlJ S Remington
May 1, 1974·The Journal of Experimental Medicine·S E Anderson, J S Remington
Mar 1, 1974·Infection and Immunity·L Bourgeois, B L Beaman
Mar 1, 1971·The American Journal of Medicine·L S YoungP Lieberman
Oct 1, 1954·The Journal of Pathology and Bacteriology·R H GORRILL, R H HEPTINSTALL
Sep 1, 1962·The Journal of Experimental Medicine·G B MACKANESS

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Citations

Mar 6, 2009·Veterinary Pathology·J A St LegerK A Terio
Jul 15, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·David A LoefflerDianne M Camp
Dec 1, 1983·The Journal of Hygiene·B L Beaman, A M Sugar
May 1, 1992·Journal of Clinical Microbiology·L Vera-CabreraM A Rodriguez
Apr 1, 1994·Clinical Microbiology Reviews·B L Beaman, L Beaman
Jun 1, 1983·Infection and Immunity·C CondeL Ortiz-Ortiz
Aug 1, 1980·Infection and Immunity·B L BeamanY Ohsugi
Jan 1, 1982·Infection and Immunity·B L BeamanR Deem
Dec 1, 1982·Infection and Immunity·R L DeemM E Gershwin
Sep 1, 1988·Infection and Immunity·C Pomeroy, G A Filice
Jun 1, 1988·Infection and Immunity·G A Filice
Jun 26, 2021·Ageing Research Reviews·Mario F Munoz-PintoSandra M Cardoso

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