Effects of activation of vasopressin-V1-receptors on regional kidney blood flow and glomerular arteriole diameters

Journal of Hypertension
A G CorreiaR G Evans

Abstract

We tested whether vasoconstriction of juxtamedullary glomerular arterioles contributes to vasopressin V1 -receptor-mediated reductions in medullary perfusion (MBF). The left kidney of pentobarbitone anaesthetized rabbits was denervated, a perivascular flow probe placed around the renal artery and laser-Doppler flow probes positioned in the inner medulla and on the cortical surface. Rabbits then received a 30 min intravenous infusion of [Phe2,Ile3,Orn8]vasopressin (V1 -AG; 30 ng/kg per min; n = 7) or its vehicle (n = 7). Kidneys were perfusion fixed at the final recorded mean arterial pressure (MAP) and filled with methacrylate casting material. Diameters of afferent and efferent arterioles were determined by scanning electron microscopy. V1 -AG increased MAP (19 +/- 3%) and reduced MBF (30 +/- 8%) but not cortical perfusion or total renal blood flow. Vehicle-treatment did not significantly affect these variables. After vehicle- and V1-AG-treatment, juxtamedullary afferent arteriole luminal diameter averaged 15.35 +/- 1.31 and 15.88 +/- 1.86 microm, respectively (P= 0.92), while juxtamedullary efferent arteriole luminal diameter averaged 17.75 +/- 1.86 and 18.36 +/- 2.24 microm, respectively (P= 0.93). V1-AG reduced MBF but did ...Continue Reading

References

Sep 1, 1992·Renal Physiology and Biochemistry·P Hansell
Dec 1, 1990·Kidney International·S Ito, O A Carretero
Jul 1, 1990·Physiological Reviews·T L PalloneR L Jamison
Aug 1, 1985·The Journal of Clinical Investigation·B ZimmerhacklR L Jamison

❮ Previous
Next ❯

Citations

Aug 10, 2004·Clinical and Experimental Pharmacology & Physiology·Kate M DentonRoger G Evans
Jun 12, 2004·Clinical and Experimental Pharmacology & Physiology·Gabriela A EppelRoger G Evans
Jul 2, 2009·Clinical and Experimental Pharmacology & Physiology·Roger G EvansNiwanthi W Rajapakse
Dec 18, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K Rahmouni, W G Haynes
Jul 17, 2004·Journal of Hypertension·Roger G EvansKate M Denton
Jun 6, 2014·American Journal of Physiology. Renal Physiology·Brendan C FryAnita T Layton
Jul 20, 2002·Journal of Cardiovascular Pharmacology·Niwanthi W RajapakseRoger G Evans
May 20, 2014·Critical Care Medicine·Ian J StewartKevin K Chung
Nov 18, 2011·American Journal of Physiology. Renal Physiology·Anita T LaytonThomas L Pannabecker
Feb 5, 2015·American Journal of Physiology. Renal Physiology·Brendan C FryAnita T Layton
Feb 28, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Niwanthi W RajapakseRoger G Evans

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved