PMID: 3760780Oct 1, 1986Paper

Effects of activation on lipoprotein lipase secretion by macrophages. Evidence for autoregulation

The Journal of Experimental Medicine
S R Behr, F B Kraemer

Abstract

Lipoprotein lipase (LPL) activity was measured in the media of cultured mouse peritoneal macrophages that were isolated after the intraperitoneal injection of inflammatory agents in order to yield a variety of states of activation. Fully activated macrophages obtained from Corynebacterium parvum-injected mice secreted very low levels of LPL when compared to unstimulated macrophages, while inflammatory and primed macrophages had increased LPL secretion. When inflammatory macrophages were incubated with conditioned medium obtained from fully activated macrophages, LPL secretion decreased in a time- and dose-dependent fashion. The factor(s) secreted by fully activated macrophages that inhibited LPL secretion was shown to be thermolabile and distinct from tumor necrosis factor. These results demonstrate that activation dramatically alters macrophage LPL secretion.

References

Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A M FogelmanP A Edwards
Jan 1, 1983·Annual Review of Biochemistry·M S Brown, J L Goldstein
Jul 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A FaggiottoL Harker
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M KawakamiA Cerami

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Citations

Oct 28, 1988·Biochimica Et Biophysica Acta·Y MurataF B Kraemer
Jun 12, 1990·Biochimica Et Biophysica Acta·L JonassonJ Etienne
Mar 14, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·S BjerregaardS Frokjaer
Apr 12, 2014·Biochimica Et Biophysica Acta·Sander Kersten
Sep 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·S IshibashiN Yamada
Jan 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·F B KraemerS R Behr
Jul 1, 1990·Metabolism: Clinical and Experimental·Y NagataA D Cooper

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