PMID: 11915923Mar 28, 2002Paper

Effects of activity on growth factor expression

International Journal of Sport Nutrition and Exercise Metabolism
G Goldspink, S Y Yang

Abstract

For some time, it has been appreciated that muscle mass is regulated locally as well as systemically. We have cloned the cDNA of two isoforms of IGF-1, which are derived from the IGF-1 gene by alternate splicing. The expression of one of these was only detectable after mechanical stimulation. For this reason, this has been called mechano growth factor (MGF). The MGF is not glycosylated, is smaller, and has a shorter half-life in the unbound state than the systemic liver type IGF-1. As the result of a reading frame shift the MGF peptide also has a different C terminal sequence and thus has different binding protein/receptor affinities. Another splice variant (muscle L.IGF-I) is expressed in muscle during rest but is also upregulated by exercise. The latter is similar to the systemic liver type IGF-1. The evidence suggests that MGF has a high potency for inducing local protein synthesis and preventing apoptosis and therefore has an important role in local tissue repair and remodeling. Our physiological experiments show that stretch and particularly stretch combined with electrical stimulation, rather than stimulation alone are important in inducing MGF expression. The mechanotransduction mechanism is believed to involve the muscl...Continue Reading

Citations

Oct 14, 2003·Journal of Applied Physiology·Frederick H SilverLorraine M Siperko
Jun 9, 2014·Biomedical Microdevices·Golnar DoroudianBrenda Russell
Mar 3, 2005·Medicine and Science in Sports and Exercise·Martyn R RubinWesley C Hymer
Feb 14, 2007·Journal of the Royal Army Medical Corps·A BennettA Mistlin
Jul 11, 2018·FEBS Open Bio·Ryan BerryStuart J Frank
Jul 28, 2007·Muscle & Nerve·Antonio Garcia SoaresAnselmo Sigari Moriscot
Jan 5, 2011·Archives of Biochemistry and Biophysics·Irina V KravchenkoVladimir O Popov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.