PMID: 16617691Apr 19, 2006Paper

Effects of acupuncture on nNOS and iNOS expression in the rostral ventrolateral medulla of stress-induced hypertensive rats

Acupuncture & Electro-therapeutics Research
Yu-Ling HuangDa-Nian Zhu

Abstract

This study was to observe the changes of the neuronal and inducible nitric oxide synthase (nNOS & iNOS) as well as their mRNAs in the rostral ventrolateral medulla (RVLM) of stress-induced hypertensive rats before and after acupuncture, and thereby to infer the curative mechanism of acupuncture on hypertension. The result indicated that the systolic blood pressure (SBP) of stress group rats was increased significantly (P < 0.01), it was accompanied that the expression of nNOS in the RVLM, including the immunoreactive neuron number (P < 0.05), the optical density (OD) (P < 0.01), and the mRNA (P < 0.01) were obviously elevated, while those of iNOS (P < 0.05, P < 0.01 and P < 0.01) were evidently lowered in the stress-induced hypertensive rats. Electroacupuncture (EA) points at "Zusanli" (St. 36) and "Lanwei" (Extra 37) on the same hindlimb were stimulated by an EA apparatus (Type G6805-2) with dense sparse wave (4-20Hz) and 4mA intensity. EA application could return the SBP (P < 0.05), and the changes on the expression of both nNOS and iNOS (P < 0.05, P < 0.01 and P < 0.01). These results suggest that the curative mechanism of acupuncture on stress-induced hypertension is related to the changes of nNOS and iNOS in the RVLM of rats.

Citations

Aug 6, 2011·Lasers in Medical Science·Thomas FriedemannWolfgang Schwarz
Jul 26, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Xuan XiongLe-Xin Wang
Apr 5, 2012·Kidney & Blood Pressure Research·Josne C PaternoVicente Paulo Castro Teixeira
Jul 19, 2008·Clinical and Experimental Pharmacology & Physiology·Chun-Mei XiaDa-Nian Zhu
Jun 2, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Jing LiXinsheng Lai
Feb 16, 2013·Acupuncture & Electro-therapeutics Research·Cinar SevercanYasemin Gündüztepe

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