PMID: 7089030May 1, 1982Paper

Effects of acute and daily cocaine administration on performance under a delayed-matching-to-sample procedure

Pharmacology, Biochemistry, and Behavior
M N Branch, M E Dearing


Food deprived pigeons were trained under a procedure in which trials began with the transillumination of one of three keys by red or green light. Pecking this key extinguished the light behind it and, after a variable delay (0.05, 0.5, 1.0, 2.0, or 4.0 sec), was followed by illumination of the two other keys, one by red light and one by green. Pecks on the key that was the same color as the previously illuminated key could produce access to food. High levels of accuracy were obtained at all delays. The acute and chronic effects of cocaine on performance generated by this procedure (delayed-matching-to-sample) were studied. Acutely, cocaine (0.56-10.0 mg/kg) produced dose-related decreases in accuracy and in rate of completing trials. Accuracy at the longest delay was more sensitive to cocaine's effects. Daily administration of a comparatively large dose (5.6 mg/kg) resulted in tolerance to the rate-reducing and accuracy-reducing effects of large doses.


Mar 15, 1977·Life Sciences·M M Kilbey, E H Ellinwood
Jan 1, 1978·European Journal of Pharmacology·S A CastellaniM M Kilbey
Sep 1, 1978·Pharmacology, Biochemistry, and Behavior·W L WoolvertonC R Schuster
Nov 1, 1976·European Journal of Pharmacology·F C ColpaertP A Janssen
Jan 1, 1966·Psychopharmacologia·C R SchusterJ H Woods


Jan 1, 1992·Psychopharmacology·E B Evans, G R Wenger
Jan 11, 1992·Psychopharmacology·P H JanakJ L Martinez
Nov 1, 1985·Pharmacology, Biochemistry, and Behavior·D M Thompson, P J Winsauer
Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·K F Schama, M N Branch
Jun 1, 1989·Pharmacology, Biochemistry, and Behavior·K M KumorJ H Jaffe
Mar 1, 1990·Pharmacology, Biochemistry, and Behavior·E B Evans, G R Wenger
Apr 11, 1992·Pharmacology, Biochemistry, and Behavior·P H Janak, J L Martinez
Oct 1, 1993·Pharmacology, Biochemistry, and Behavior·G R WengerD W Wright
Jun 1, 1994·Pharmacology, Biochemistry, and Behavior·M MakhayA Poling
Sep 1, 1995·Pharmacology, Biochemistry, and Behavior·A F NordholmG R Wenger
Apr 28, 2001·Pharmacology, Biochemistry, and Behavior·P L QuirkD D Avery
May 1, 1997·Pharmacology, Biochemistry, and Behavior·N E GoedersG F Guerin
Sep 1, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Pascal RomieuTangui Maurice
Jul 1, 1988·Pharmacology, Biochemistry, and Behavior·M N Branch, G M Sizemore
Sep 11, 2013·Journal of the Experimental Analysis of Behavior·Vanessa Minervini, M N Branch
Dec 1, 1988·Biological Psychiatry·M A Sherer
Apr 16, 1993·Brain Research·D A SmithT V Dunwiddie
Jan 25, 2003·Psychopharmacology·Rajeev I Desai, Philip Terry
Mar 6, 2012·Journal of the Experimental Analysis of Behavior·Brian D Kangas, M N Branch
Sep 26, 2012·Journal of the Experimental Analysis of Behavior·Brian D Kangas, M N Branch
Mar 1, 1996·Journal of the Experimental Analysis of Behavior·D J Walker, M N Branch
Sep 1, 1991·Journal of the Experimental Analysis of Behavior·C E Hughes, M N Branch
Jul 1, 1995·Journal of the Experimental Analysis of Behavior·D W SchaalA L Odum
Feb 1, 2011·Journal of the Experimental Analysis of Behavior·Brian D KangasM N Branch
May 5, 2011·Journal of the Experimental Analysis of Behavior·Brian D KangasM N Branch
May 1, 1987·Journal of the Experimental Analysis of Behavior·S H HoffmanG M Sizemore
Jun 1, 1985·The International Journal of the Addictions·J Grabowski, S I Dworkin

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