Effects of acute and subchronic d-amphetamine on ventral striatal concentrations of neurotensin and neuropeptide Y in rats treated with antipsychotic drugs

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Susanne H M GruberA A Mathé

Abstract

We have reported that acute d-amphetamine increases extracellular concentrations (efflux) of neurotensin-like immunoreactivity (NT-LI) and neuropeptide Y-LI (NPY-LI) in the ventral striatum (VSTR) of freely moving rats, effects that are abolished by chronic administration of haloperidol and risperidone admixed to food pellets. In this study we further investigated the d-amphetamine effects on NT-LI and NPY-LI efflux in VSTR and their content in selected brain regions. Rats received haloperidol, risperidone or vehicle for 30days and saline or d-amphetamine either on days 22-29 and/or day 30. Seven day d-amphetamine administration decreased basal NT-LI and NPY-LI efflux in vehicle-treated rats; pretreatment with haloperidol counteracted these effects, while pretreatment with risperidone had effect only on NT-LI. Acute d-amphetamine after the seven day d-amphetamine increased NT-LI only. Pretreatment with haloperidol or risperidone abolished the effects of acute d-amphetamine on NT-LI and NPY-LI. Acute and seven day d-amphetamine increased NT-LI and NPY-LI contents in striatum; seven day d-amphetamine also increased NT-LI in frontal and occipital cortex and both NT-LI and NPY-LI in hippocampus. Our results suggest that NT and NPY ...Continue Reading

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Citations

Aug 10, 2011·Clinical Nuclear Medicine·Valentina GaribottoOsman Ratib
Nov 18, 2011·Journal of Pharmaceutical and Biomedical Analysis·Xingguo ZhangFanzhu Li
Feb 15, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Susanne H M GruberAleksander A Mathé
Oct 6, 2009·Analytica Chimica Acta·Maura PerryRobert T Kennedy

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