Effects of acute, chronic ethanol and withdrawal on dorsal raphe neurons: electrophysiological studies

Neuroscience
M PistisM Diana

Abstract

The effect of a single intravenous administration of ethanol (0.25-1.0 g/kg) on the spontaneous activity of putative serotonin neurons of the dorsal raphe nucleus was studied in unanesthetized rats. Ethanol produced a slight but progressive decline in neuronal activity in 67% (six of nine) of all neurons tested. The remaining 33% (three of nine) were unresponsive. Upon withdrawal of chronic ethanol treatment (1-5 g/kg every 6 h for six consecutive days, 12 h from last ethanol administration), the mean firine rate of dorsal raphe neurons was found to be significantly reduced, by about 30% (n=71), as compared with the control group (n=83), whereas the cells/track index was unaltered. Under these conditions, ethanol administration further reduced firing rate in 67% (four of six) of all the neurons tested. In the remaining 33% (two of six), no response was observed. At 72 h after the last ethanol administration, the mean firing rate of dorsal raphe neurons was found to be within control values (n=90). Further, to evaluate the functional status of the autoreceptors under control conditions and after withdrawal from chronic ethanol, the selective serotonin-1A receptor agonist 8-hydroxy-(2-di-n-propylamino)tetralin was administered in...Continue Reading

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Citations

Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·C P BaileyH J Little
Dec 17, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Julia C LemosSheryl G Beck
Jun 24, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francis Rodriguez BambicoGabriella Gobbi
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Nov 23, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Edward P MaguireDelia Belelli
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Jan 17, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Francis Rodriguez BambicoGabriella Gobbi
Jun 27, 2015·Neuropharmacology·Claudia SaghedduMarco Pistis
Dec 20, 2008·Journal of Neurochemistry·Sabah KelaïLaurence Lanfumey
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Nov 1, 2011·Neuroscience and Biobehavioral Reviews·Thibault RenoirLaurence Lanfumey
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Jan 30, 2015·Frontiers in Neuroscience·Sheketha R HauserEric A Engleman
Jun 29, 2016·Brain Plasticity·Arnauld BelmerSelena E Bartlett

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